Lifeboat Foundation

A new longevity focused venture capital fund is preparing to announce its first investments, as it seeks to accelerate commercialisation in the field. Joining the likes of Maximon, Apollo and Korify, New York’s Life Extension Ventures (LifeX) has put together a $100 million fund specifically for companies developing solutions to extend the longevity of both humans and our planet. In a slight twist, the fund is predominantly looking to invest in companies that are leveraging software and data at the heart of their efforts to hasten the adoption of scientific breakthroughs in longevity.

Longevity. Technology: The longevity field is alive with innovation, and developments in AI and Big Data are just some of the software-led technologies driving progress throughout the sector. Co-founded by scientists-turned-entrepreneurs, Amol Sarva and Inaki Berenguer, LifeX Ventures’ investment philosophy draws on their combined experiences building software-led companies across a wide range of sectors. We caught up with Sarva to learn more.

Between them Sarva, a cognitive scientist by training, and Berenguer have led and/or founded several startups, such as CoverWallet, Virgin Mobile USA and Halo Neuroscience. The two have also invested personally in more than 150 startups before their interest turned more recently to longevity.

The twisty eruption of a dying star has finally been revealed in all its 3D glory.

A team of scientists led by a high school graduate has reconstructed the complicated and mysterious nebulae that make up one of the most famous stellar ghosts in the sky – the Cat’s Eye Nebula.

Their model revealed the mechanisms that carved out some of the previously unexplained aspects of the nebula’s structure.

https://www.youtube.com/watch?v=Ucw19Wc5K-o

Impaired reduction/oxidation (redox) metabolism is a key contributor to the etiology of many diseases, including primary mitochondrial disorders, cancer, neurodegeneration, and aging. However, mechanistic studies of redox imbalance remain challenging due to limited strategies which can perturb cellular redox metabolism and model pathology in various cellular, tissue, or organismal backgrounds without creating additional and potentially confounding metabolic perturbations. To date, most studies involving impaired redox metabolism have focused on oxidative stress and reactive oxygen species (ROS) production; consequently, less is known about the settings where there is an overabundance of reducing equivalents, termed reductive stress. NADH reductive stress has been modeled using pharmacologic inhibition of the electron transport chain (ETC) and ethanol supplementation. Still, both these methods have significant drawbacks. Here, we introduce a soluble transhydrogenase from E. coli (Ec STH) as a novel genetically encoded tool to promote NADH overproduction in living cells. When expressed in mammalian cells, Ec STH, and a mitochondrially-targeted version (mito Ec STH), can elevate the NADH/NAD⁺ ratio in a compartment-specific manner. Using this tool, we determine the metabolic and transcriptomic signatures of NADH reductive stress in mammalian cells. We also find that cellular responses to NADH reductive stress, including blunted proliferation, are dependent on cellular background and identify the metabolic reactions that sense changes in the cellular NADH/NAD⁺ balance. Collectively, our novel genetically encoded tool represents an orthogonal strategy to perturb redox metabolism and characterize the impact on normal physiology and disease states.

The authors have declared no competing interest.

Mild, persistent inflammation in tissue is considered one of the biological hallmarks of the aging process in humans—and at the same time is a risk factor for diseases such as Alzheimer’s or cancer. Prof. Francesco Neri and Dr. Mahdi Rasa of the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena have succeeded for the first time in describing at the molecular level the regulatory network that drives the general, multiple-organ inflammatory response. Moreover, they were able to show that dietary restriction can influence this regulatory circuit, thereby inhibiting inflammation.

Inflammation is an immune response of the body that is, in itself, useful: our immune system uses it to fight pathogens or to remove damaged cells from tissue. Once the immune cells have done their work, the inflammation subsides: the infection is over, the wound is healed. Unlike such acute inflammations, age-related chronic inflammation is not local. The innate immune system ramps up its activity overall, resulting in chronic low-grade inflammation. This aging-related inflammation is also known as inflammaging.

That was Aubrey de Grey, this is Aubrey de White. New foundation, new therapy tests.

Co-founder of the SENS Foundation, Dr Aubrey de Grey is the co-organiser of this week’s Longevity Summit Dublin 2022; he was keynote speaker at this week’s summit, speaking on Robust Mouse Rejuvenation: real soon now? and featuring on the panel discussion Blank Cheque, which also enjoyed contributions from our own Phil Newman, Michael West, Tom Weldon, Greg Grinberg and Evelyne Bischof.

Continue reading “Aubrey de Grey on why Aubrey 3.0 is about racing towards milestones and a brand-new foundation” »

Ralph C. Merkle is a computer scientist. He is one of the inventors of public key cryptography, the inventor of cryptographic hashing, and more recently a researcher and speaker of cryonics.

Videos in the talk: David Eagleman https://www.youtube.com/watch?v=-5tZtYns6kE molecular nanotechnology: https://www.youtube.com/watch?v=zqyZ9bFl_qg.

Filmed 2017/04/30

University of Buffalo scientists have undertaken a study that shows a process to reverse aging in muscle cells. Aging in muscle cells is a function of…

Eleven-year-old Simons only took a year to complete his bachelor’s degree, which usually takes at least three years.

In a conversation with the Dutch daily De Telegraaf, Simons said that, “I don’t really care if I’m the youngest.” “It’s all about getting knowledge for me.”

“This is the first puzzle piece in my goal of replacing body parts with mechanical parts,” Simons said.