Lifeboat Foundation

Year 2017 This is essentially the mechanism for plant immortality.

RNA-directed DNA methylation (RdDM) activity in the Arabidopsis thaliana male sexual lineage that regulates gene expression in meiocytes. Loss of sexual-lineage-specific RdDM causes mis-splicing of the MPS1 gene (also known as PRD2), thereby disrupting meiosis. Our results establish a regulatory paradigm in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls gene expression and contributes to cellular function in flowering plants.

Year 2017 Basically the tardigrade is the most promising set of genes on any creature due to many types of survival genes like going years without food or even genes for radiation resistance which could be used in crispr to augment human genes.

Tardigrades — aka water bears or moss piglets — are perhaps the most resilient creatures on the planet, able to survive complete dehydration, space vacuum and being frozen. However, only recently have scientists begun to unravel the genes that underpin the tardigrade’s biological superpowers. “They’re 0.2mm to 1mm in length and despite being so small they are able to do all these things we cannot,” says Mark Blaxter, a biologist at the University of Edinburgh who has been studying tardigrades for 20 years. “In their DNA, they hold a cornucopia of secrets.”

With Kazurahu Arakawa, from the University of Keio, Japan, Blaxter recently analysed the first true tardigrade genome. The results, published today in the open access journal PLOS Biology, are a first step towards explaining the genetics underpinning the tardigrade’s extraordinary resilience and to pinpoint its place within the evolutionary tree of life. We spoke to Blaxter about his new research and his fascination for this remarkable little animal.

Continue reading “How tardigrades come back from the dead” »

Let’s not just cure cancer: let’s cure aging One of the most exciting areas of modern scientific research is the investigation of the causes and cures for aging. Not individual diseases like cancer and heart disease, but the processes which make us elderly and frail, and which thereby make us more susceptible to these diseases.

Short version: One treated rat is sill alive and equivalent to a 110 year old human.

In this video we review the latest updates from Dr Katcher’s Lifespan trials and NEEL clinical trials.
NTZ Newsletter.
https://www.ntzplural.com/newsletter.
NEEL website.
https://www.neel.bio.

Continue reading “Dr Katcher’s E5 Experiment November 2022 Update” »

After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are available as oral agents, PCSK9 inhibitors can only be administered as injections, creating barriers to their use.

Longevity. Technology: Having high cholesterol can increase the risk of heart and circulatory diseases such as heart attack, stroke and vascular dementia, but a new study from investigators at University Hospitals (UH) and Case Western Reserve University School of Medicine details an orally administered small-molecule drug that reduces PCSK9 levels and lowers cholesterol in animal models by 70%. Published in Cell Reports, the findings represent a previously unrecognised strategy for managing cholesterol and may also impact cancer treatments.

Cardiovascular disease ranking as the world’s number one killer, so it’s no surprise that a significant amount of research into potential therapeutic options is ongoing; just last week we looked at Cyclarity’s rationally-designed cyclodextrin molecules that remove arterial plaque by clearing the non-degradable oxidised cholesterol and which can be used in conjunction with statins for a broad-spectrum approach. Our report into Cyclarity’s new platform comes out next week, so stay tuned!

Research from the Babraham Institute has developed a method to “time jump” human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute’s Epigenetics research program has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today in the journal eLife, and while this topic is still at an early stage of exploration, it could revolutionize regenerative medicine.

What is regenerative medicine?

As we age, our cells’ ability to function declines and the genome accumulates marks of aging. Regenerative biology aims to repair or replace cells including old ones. One of the most important tools in regenerative biology is our ability to create “induced” stem cells. The process is a result of several steps, each erasing some of the marks that make cells specialized. In theory, these stem cells have the potential to become any cell type, but scientists aren’t yet able to reliably recreate the conditions to re-differentiate stem cells into all cell types.

Talk kindly contributed by Michael Levin in SEMF’s 2022 Spacious Spatiality.

https://semf.org.es/spatiality.

Continue reading “Michael Levin | Cell Intelligence in Physiological & Morphological Spaces” »

Dr. Dobri Kiprov about Therapeutic Plasma Exchange: New video from our 2022 #RejuvenationStartupSummit. Dobri is CSO at Lyfspn and an internationally renowned pioneer and expert in Therapeutic Apheresis, Immunotherapy, and Age-Related Disorders.

Enjoy -> https://lnkd.in/e_PZAsMm.

Continue reading “Dobri Kiprov at Rejuvenation Startup Summit 2022” »

The terms lifespan and longevity are often used interchangeably, which leads to much confusing and misinformation. Here we explore the difference between the two terms and why making a distinction is important.