Lifeboat Foundation

How LLM #AI can make a patient-friendly— more understandable, more concise— hospital discharge summary for patients.

Generative artificial intelligence to transform inpatient discharge summaries to patient-friendly language and format.

This cross-sectional study, as part of a larger project to improve care delivery in our health system, was deemed exempt from institutional review board review based on the NYU Langone Health self-certification protocol. The study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.

Continue reading “Generative AI for Patient-Friendly Language in Discharge Summaries” »

From creating images, generating text, and enabling self-driving cars, the potential uses of artificial intelligence (AI) are vast and transformative. However, all this capability comes at a very high energy cost. For instance, estimates indicate that training OPEN AI’s popular GPT-3 model consumed over 1,287 MWh, enough to supply an average U.S. household for 120 years.

High-intensity exercise induces brain-protective effects that have the potential to not just slow down but possibly reverse the neurodegeneration associated with Parkinson’s disease, a new pilot study suggests.

Prior research has shown that many forms of exercise are linked to improved symptoms of Parkinson’s disease. But there has been no evidence that hitting the gym could create changes at the brain level. Now, a small proof-of-concept study involving 10 patients showed that high-intensity aerobic exercise preserved dopamine-producing neurons, the brain cells that are most vulnerable to destruction in patients with the disease.

In fact, after six months of exercise, the neurons actually had grown healthier and produced stronger dopamine signals. Dopamine is a chemical that helps brain cells communicate with one another. The researchers published their findings in npj Parkinson’s Disease on February 9.

Is there a connection between vaping cigarettes or cannabis, irregular mealtimes, and frequent headaches in individuals under 18 years of age? This is what a recent study published in the journal Neurology hopes to address as a team of researchers from the University of Calgary investigated how lifestyle choices combined with vaping could result in frequent headaches among youth. This study holds the potential to help researchers, medical professionals, and the public better understand the short-and long-term health risks associated with vaping cigarettes or cannabis.

For the study, the researchers enlisted 4,978,370 participants aged between 5 and 17 years for a health survey with the goal of ascertaining a connection between lifestyle choices—vaping, irregular mealtimes, and extended periods of screen time—and the frequency of headaches they reported as part of the survey. In the end, the researchers found that 6.1 percent of the participants experienced frequent headaches who also exhibited the aforementioned lifestyle choices, specifically including e-cigarettes and smoking in the house.

“These results are important because there is surprisingly little research looking at lifestyle and headaches in kids and teens,” said Dr. Serena Orr, MD, who is an assistant professor of pediatrics, community health sciences, and clinical neurosciences at the University of Calgary and a co-author on the study. “As a headache neurologist, I think that it’s critical to understand the role that lifestyle factors play, because prescribing medication alone is not the ideal way of treating headaches at any age.”

Rates increased among all age groups, including newborns, and in all regions of the country. In 2022, 3,755 cases of babies born with syphilis in the U.S. were reported, which reflects an alarming 937% increase in the past decade, the CDC said.

The report continued that racial and ethnic minorities are most disproportionately affected due to “long standing social inequities that often lead to health inequalities.”

Combined, infection, autoimmunity and cancer account for 4 out of every 10 deaths worldwide, and represent major global health challenges. In a paper in the journal Cell Reports, Institute for Systems Biology (ISB) researchers highlight a novel discovery of how the human immune system works in common ways across diseases, and offer promising avenues for exploring multi-disease therapeutic strategies.

Many therapies, while effective for one class of disease, may aggravate others. Cancer treatments like immune checkpoint blockade, for example, can trigger autoimmunity. Similarly, drugs targeting autoimmune diseases may leave patients more susceptible to infections and cancer.

Continue reading “Common immune response is found to be protective across many diseases” »

Cervical cancer, which develops in the lower portion of the uterus, known as the cervix, typically grows slowly. Cells in the cervix can change, a process known as dysplasia, and the resulting abnormal cells, if not removed, can develop into cervical cancer.

When cervical cancer occurs, treatment options vary based on many factors, including how far the disease has advanced and the overall health of the patient. Some cervical cancer patients may undergo a simple hysterectomy (also known as a complete or total hysterectomy). A simple hysterectomy removes the uterus and cervix.

The perimetrium, fat and connective tissue around the uterus, connects the uterus to the cervix and other tissues. Some patients with cervical cancer experience “parametrial invasion” (also referred to as parametrial infiltration), during which cervical cancer has spread into the parametrial tissue.

The elevated cardiovascular disease risk among people with HIV is even greater than predicted by a standard risk calculator in several groups, including Black people and cisgender women, according to analyses from a large international clinical trial primarily funded by the National institutes of Health and presented at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver. The risk of having a first major cardiovascular event was also higher than previously predicted for people from high-income regions and those whose HIV replication was not suppressed below detectable levels.

Researchers examined the incidence of major adverse cardiovascular events in people who did not take pitavastatin or other statins during the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) trial, a large clinical trial to test whether pitavastatin—a cholesterol-lowering drug known to prevent cardiovascular disease—could prevent major adverse cardiovascular events, such as heart attacks and strokes, in people with HIV. The scientists compared the incidence of cardiovascular events in the trial to the incidence predicted by standard estimates, which use the American College of Cardiology and American Heart Association’s Pooled Cohort Risk Equations (PCE) score.

They found that the rate of cardiovascular events occurring in many groups of people differed from predicted rates, even considering that people with HIV have a higher overall risk of cardiovascular disease than people without HIV, including double the risk of major adverse cardiovascular events. Notably, in high-income regions—as defined by the global burden of disease classification system—including North and South America and Europe, cardiovascular event rates were higher overall, with cisgender women experiencing about two and a half times more events than predicted, and Black participants having more than 50% higher event rates than predicted.

NIH-supported study shows long-term benefits of surgery compared to medication and lifestyle change.

People with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to people who received medical management plus lifestyle interventions, according to a new study supported by the National Institutes of Health. The participants who underwent bariatric surgery, also called metabolic or weight-loss surgery, were also more likely to stop needing diabetes medications and had higher rates of diabetes remission up to 12 years post-surgery. Results of the study were published in JAMA and funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of NIH.

“While there are many factors involved, and not all of them are completely understood, bariatric surgery typically results in greater weight loss that affects a person’s metabolic hormones, which improves the body’s response to insulin and ability to maintain healthy blood glucose levels,” said Dr. Jean Lawrence, NIDDK project scientist. “These results show that people with overweight or obesity and type 2 diabetes can make long-term improvements in their health and change the trajectory of their diabetes through surgery.”