Lifeboat Foundation

Not everyone wants to sleep in. A growing transhumanism community wants to sleep less, and better, and they’re going to great lengths to make it happen.

For those unaware, transhumanism is an intellectual and cultural movement that aims to improve the human condition, to push beyond our biological limitations, largely through technological advancements. They’re particularly focused on extreme longevity. But with treatments for an extended healthy life still works in progress (and playing out on a very long timeline), some transhumanists have turned their attention to sleep.

The average well-rested person sleeps eight hours a day. The average American lives 79 years. That’s a little more than just 50 years being awake. Life is much shorter than you realized — at least if you agree with your typical sleep-hacker that sleeping is wasted downtime.

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Our gut and the microbiome play a crucial role in our health, but could better understanding of that role help us avoid disease and live longer?

The microbiome weighs 2–3 pounds and contains 10 times more cells than our own, but we’ve neglected our microbial tenants for a long time. These little denizens help us break down food, provide key nutrients and even play a role in inflammation and the integrity of our intestinal tract. It’s no surprise then that fermented foods and probiotics are gaining popularity as we become more aware of how important our gut is. Recent evidence even links poor digestive health to chronic inflammation and Parkinson’s disease.

New research suggests that both gut integrity, and the amount and type of bacteria that reside within it, can actually predict an individual’s health. They may even quicken or slow the pace of aging.

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Progress always seems to ride a slippery slope. Innovations generally bring a plethora of potential benefits and just as many dangers, the obvious and the hidden. Technologies that tamper with our biological constructs is well underway in the neuro- and biotech industries. Historically, innovations in medicine have usually been beneficial on the aggregate.

But these new breakthroughs go beyond preventing and healing pre-existing causes. Transhuman technologies hold the promise of enhancing who we are as individuals and potentially as an entire species, and the decisions surrounding these technologies are far from simple. Dr. Nayef Al-Rodhan, a philosopher, neuroscientist, and director of the Geneva Center for Security Policy, believes we should be acting now to prepare for the inevitable and the unpredictable ramifications.

Framing Human Motivation

Considering our mixed track record as a species in rolling out groundbreaking innovations, discussing and finding potential solutions to many of the hidden dangers, and obvious ones, seems more than reasonable. One of the more puzzling questions is, where do we begin to have a pragmatic conversation on the ethics of these technologies?

There are plenty of theories about what drive human decisions, not least because human morality is infinitely complex and our minds crave frames through which to make sense of chaos. Dr. Al-Rodhan has his own conception of what drives human motivations. He makes meaning using the lens of “5 P’s” – Power, Pride, Profit, Pleasure, and Permanence – which he posits drive human motivations. “This is my view, the foundation of my outlook…this perceived emotion of self interest drives our moral compass.”

Continue reading “The Imminence of Transhuman Technologies” »

Dr Michael Fossel is a PhD and MD heading up telomerase research and therapy and has kindly written a blog article for Bioviva detailing the work both they and his company Telocyte are doing to fight back against Alzheimer’s.

How Alzheimer’s Can Be Prevented and Cured…

Michael Fossel, MD, PhD

As I said in my medical textbook on aging, “If age is a thief, then the greatest treasure we lose is ourselves.” We fear Alzheimer’s not simply because it takes away our health, but because it steals our souls.

Continue reading “Curing Alzheimer's” »

Everything starts to go downhill as we get older and muscle is no exception; even simple tasks become challenging as we lose bone and muscle. Now research has identified a protein behind this age-related decline and therapeutic molecules that can fight it, helping individuals stay healthy and strong for longer.

A team at the Univesity of Iowa has discovered that a protein called ATF4 might be behind muscular decline. ATF 4 is a transcription factor, which means it tells the body to activate or regulate certain genes. ATF4 seems to change skeletal muscle with age, reducing protein synthesis and overall mass.

”Many of us know from our own experiences that muscle weakness and atrophy are big problems as we become older”

Continue reading “Aging Causes Muscle Weakness And Atrophy, But Can We Treat It?” »

Sure, it can beat Ken Jennings at Jeopardy, tell you about your city, and dream up recipes for delectable delicacies, but now, IBM’s Watson is doing something even more important than all previous capabilities combined — it’s finally getting closer to becoming your doctor. Last April, the century-old company launched IBM Watson Health, and now, it’s opened up a new office in Cambridge, Massachusetts, home to some of the best universities in the U.S., and some of the most impressive biotech and pharmaceutical companies as well. In the last few months, Watson has already expanded its scope to take on some of our most pressing health issues and diseases, including cancer and diabetes, and with this new establishment, it seems that the supercomputer will only be taking on greater responsibilities in the industry.

More exciting still is the announcement that Deborah DiSanzo, the former CEO of Philips Healthcare, will be leading the unit as its general manager. Under her leadership, IBM hopes that Watson Health will be able to grow and further expand its massive cloud computing capabilities, which the company believes holds significant potential for modern health care. While current “health record systems can do great job storing data,” Mike Rhodin, senior vice president of the IBM Watson Group, told Fortune, “Watson can summarize that data and incorporate nurse and doctor’s notes to give a more complete picture.”

Related: IBM is bringing sports into the digital age, starting with the U.S. Open.

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And Can We Use Them To Improve Health and Longevity

Junk DNA may play a critical role in the creation of new DNA.

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Checkout the latest Longevity Reporter Newsletter (05th September, 2015), covering this week’s top news in health, aging, longevity.

This week: Dramatic Advances In Super-Resolution Imaging; This Stunning 3-D Model Provides A Fresh Perspective On Cancer; Want A Long Lifespan? You Need Stable Gene Networks; The Future Of Health: Precision Medicine; And more.

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You may have heard of precision medicine in the news, but what actually is it, and what could it mean for the future of healthcare?

In the past, medicine was geared for the masses and was applied to large numbers of people, on the basis of average effectiveness. If a particular substance was ineffective on 10% of the population, it could still pass through and be prescribed anyway. Before genomics, it was tricky to understand or postulate why people had such varied responses to medication, but now we have the right tools — things are changing.

While all humans have extremely similar genes in percentage terms, there are distinct differences in each of us that create our particular vulnerabilities and characteristics. We also respond differently to many treatments; a cure for one might be mediocre for another. This is particularly true for cancer. With the Precision Medicine Initiative taking off, taking into account genetics, lifestyle and environment is beginning to give us an edge — making medicine more accurate and effective.

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