Lifeboat Foundation

While some cholesterol is a healthy thing for properly functioning cells, too much of it can cause blockages in the arteries and heart trouble, along with a host of other negative health outcomes. Scientists have discovered a new mechanism by which a “bad” type of cholesterol gains entry to the cells, identifying a pair of proteins that work like an entry tunnel. These proteins show promise as new targets for drugs that could lower cholesterol levels in the blood to help prevent disease.

The discovery made by an international team of researchers was only possible thanks to advances in imaging technology that enabled them to inspect proteins at a near-atomic level. In this case, the team were investigating the role two proteins, NPC1 and NPC2, play in transporting low-density lipoprotein (LDL) cholesterol, often referred to as “bad” cholesterol, into our cells.

“Before 2013 we often had to theorise about how membrane proteins worked and how they functioned, but now we can actually see them, and seeing is believing,” says study author Prof Rob Yang from the UNSW in Australia. “We were able to look at the NPC1 and NPC2 proteins and see exactly the role they play in transporting this LDL cholesterol into the cell.”

The loose alliance, whose backers include Infosys Ltd. co-founders Nandan Nilekani and Kris Gopalakrishnan as well as prominent startups from Practo to Policybazaar, will be formally unveiled as soon as this week in an attempt to salvage a decrepit system by digitizing everything from patient data and records to creating online platforms for hospital care and doctor consultations. Called Swasth — meaning health in Hindi — its 100-plus members have pledged to build new services and coordinate efforts to improve emergency responses.

Some of India’s richest people form an alliance with tech entrepreneurs to fix the country’s broken healthcare system.

The role genetics and gut bacteria play in human health has long been a fruitful source of scientific enquiry, but new research marks a significant step forward in unraveling this complex relationship. Its findings could transform our understanding and treatment of all manner of common diseases, including obesity, irritable bowel syndrome, and Alzheimer’s disease.

The international study, led by the University of Bristol and published today in Nature Microbiology, found specific changes in DNA — the chains of molecules comprising our genetic make-up — affected both the existence and amount of particular bacteria in the gut.

Lead author Dr David Hughes, Senior Research Associate in Applied Genetic Epidemiology, said: “Our findings represent a significant breakthrough in understanding how genetic variation affects gut bacteria. Moreover, it marks major progress in our ability to know whether changes in our gut bacteria actually cause, or are a consequence of, human disease.”

With a new nanoparticle that converts light to heat, a team of researchers has found a promising technology for clearing water of pollutants.

Trace amounts of contaminants such as pesticides, pharmaceuticals and perfluorooctanoic acid in drinking water sources have posed significant health risks to humans in recent years. These micropollutants have eluded conventional treatment processes, but certain chemical processes that typically involve ozone, hydrogen peroxide or UV light have proven effective. These processes, however, can be expensive and energy-intensive.

A new nanoparticle created by Yale University engineers as part of an effort for the Rice-based Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment (NEWT) could lead to technologies that get around those limitations. The particle is described in a study published this week in the Proceedings of the National Academy of Sciences.

https://www.youtube.com/watch?v=rnfmIkvsDoQ&feature=youtu.be

Liz Parrish and Integrated Health Systems discuss the thymus, an organ that is essential to healthy immune function.

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CLEW, an Israeli medtech firm specializing in real-time AI analytics platforms, received approval from the United States Food and Drug Administration (FDA) for its “Predictive Analytics Platform in Support of COVID-19 Patients,” the company announced Tuesday.

The Intensive Care Unit (ICU) solution was given Emergency Use Authorization (EUA) by the FDA so that it may be implemented within the United States’ health system as soon as possible.

In other words, practicing the arts can be used to build capacity for managing one’s mental and emotional well-being.

Neuroesthetics — With recent advances in biological, cognitive, and neurological science, there are new forms of evidence on the arts and the brain. For example, researchers have used biofeedback to study the effects of visual art on neural circuits and neuroendocrine markers to find biological evidence that visual art promotes health, wellness, and fosters adaptive responses to stress.

Data governs our lives more than ever. But when it comes to disease and death, every data point is a person, someone who became sick and needed treatment.

Recent studies have revealed that people suffering from the same disease category may have different manifestations. As doctors and scientists better understand the reasons underlying this variability, they can develop novel preventive, diagnostic and therapeutic approaches and provide optimal, personalized care for every patient.

To accomplish this goal often requires broadscale collaborations between physicians, basic researchers, theoreticians, experimentalists, computational biologists, computer scientists and data scientists, engineers, statisticians, epidemiologists and others. They must work together to integrate scientific and medical knowledge, theory, analysis of medical big data and extensive experimental work.

Continue reading “Israeli researchers explain how they are healing the world with precision” »

“Now, nearly 2,000 people in and around Leticia are sick with COVID-19. About 70 have died. That might not sound like a colossal death toll at first. But because the surrounding state of Amazonas is sparsely populated, this amounts to the highest per-capita death rate in all of Colombia, according to figures from Colombia’s Health Ministry.”

The governor of Amazonas, Colombia, says it was impossible to cut the area off from Brazil, even as the virus spiked. Now the Colombian border town of Leticia is a coronavirus hot spot.

Continue reading “The Coronavirus Is Spreading Through Indigenous Communities In The Amazon” »