Lifeboat Foundation

In this essay I argue that technologies and techniques used and developed in the fields of Synthetic Ion Channels and Ion Channel Reconstitution, which have emerged from the fields of supramolecular chemistry and bio-organic chemistry throughout the past 4 decades, can be applied towards the purpose of gradual cellular (and particularly neuronal) replacement to create a new interdisciplinary field that applies such techniques and technologies towards the goal of the indefinite functional restoration of cellular mechanisms and systems, as opposed to their current proposed use of aiding in the elucidation of cellular mechanisms and their underlying principles, and as biosensors.

In earlier essays (see here and here) I identified approaches to the synthesis of non-biological functional equivalents of neuronal components (i.e. ion-channels ion-pumps and membrane sections) and their sectional integration with the existing biological neuron — a sort of “physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid membranes (i.e. lipid bilayer). The potential uses for such channels commonly listed in the literature have nothing to do with life-extension however, and the field is to my knowledge yet to envision the use of replacing our existing neuronal components as they degrade (or before they are able to), rather seeing such uses as aiding in the elucidation of cellular operations and mechanisms and as biosensors. I argue here that the very technologies and techniques that constitute the field (Synthetic Ion-Channels & Ion-Channel/Membrane Reconstitution) can be used towards the purpose of the indefinite-longevity and life-extension through the iterative replacement of cellular constituents (particularly the components comprising our neurons – ion-channels, ion-pumps, sections of bi-lipid membrane, etc.) so as to negate the molecular degradation they would have otherwise eventually undergone.

While I envisioned an electro-mechanical-systems approach in my earlier essays, the field of Synthetic Ion-Channels from the start in the early 70’s applied a molecular approach to the problem of designing molecular systems that produce certain functions according to their chemical composition or structure. Note that this approach corresponds to (or can be categorized under) the passive-physicalist sub-approach of the physicalist-functionalist approach (the broad approach overlying all varieties of physically-embodied, “prosthetic” neuronal functional replication) identified in an earlier essay.

The field of synthetic ion channels is also referred to as ion-channel reconstitution, which designates “the solubilization of the membrane, the isolation of the channel protein from the other membrane constituents and the reintroduction of that protein into some form of artificial membrane system that facilitates the measurement of channel function,” and more broadly denotes “the [general] study of ion channel function and can be used to describe the incorporation of intact membrane vesicles, including the protein of interest, into artificial membrane systems that allow the properties of the channel to be investigated” [1]. The field has been active since the 1970s, with experimental successes in the incorporation of functioning synthetic ion channels into biological bilipid membranes and artificial membranes dissimilar in molecular composition and structure to biological analogues underlying supramolecular interactions, ion selectivity and permeability throughout the 1980’s, 1990’s and 2000’s. The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of “in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others” through the “… transduction of bioelectrical and biochemical events into measurable electrical signals” [2].

Continue reading “Intimations of Imitations: Visions of Cellular Prosthesis & Functionally-Restorative Medicine” »

Prologue:

‘Let there be light,’ said the Cgi-God, and there was light…and God Rays.

We were out in the desert; barren land, and our wish was that it be transformed into a green oasis; a tropical paradise.

Continue reading “Recreating Heaven and Earth...in real-time.” »

This essay was also published by the Institute for Ethics & Emerging Technologies and by Transhumanity under the title “Is Price Performance the Wrong Measure for a Coming Intelligence Explosion?”.

Introduction

Most thinkers speculating on the coming of an intelligence explosion (whether via Artificial-General-Intelligence or Whole-Brain-Emulation/uploading), such as Ray Kurzweil [1] and Hans Moravec [2], typically use computational price performance as the best measure for an impending intelligence explosion (e.g. Kurzweil’s measure is when enough processing power to satisfy his estimates for basic processing power required to simulate the human brain costs $1,000). However, I think a lurking assumption lies here: that it won’t be much of an explosion unless available to the average person. I present a scenario below that may indicate that the imminence of a coming intelligence-explosion is more impacted by basic processing speed – or instructions per second (ISP), regardless of cost or resource requirements per unit of computation, than it is by computational price performance. This scenario also yields some additional, counter-intuitive conclusions, such as that it may be easier (for a given amount of “effort” or funding) to implement WBE+AGI than it would be to implement AGI alone – or rather that using WBE as a mediator of an increase in the rate of progress in AGI may yield an AGI faster or more efficiently per unit of effort or funding than it would be to implement AGI directly.

Loaded Uploads:

Continue reading “How Could WBE+AGI be Easier than AGI Alone?” »

Emotions and Longevity:

If the picture header above influenced you to click to read more of this article, then it establishes at least part of my hypothesis: Visual stimuli that trigger our primal urges, supersede all our senses, even over-riding intellect. By that I mean, irrespective of IQ level, the visual alone and not the title of the essay will have prompted a click through –Classic advertising tactic: Sex sells.

Yet, could there be a clue in this behavior to study further, in our quest for Longevity? Before Transhumanism life extension technology such as nano-tech and bio-tech go mainstream… we need to keep our un-amped bodies in a state of constant excitement, using visual triggers that generate positive emotions, thereby hopefully, keeping us around long enough to take advantage of these bio-hacks when they become available.

Continue reading “Digitizing Emotions — Longevity and the Transhuman” »

There is a real power in the act of physically moving. In so doing, each and every morning I can escape the cacophonous curse of the ubiquitous ESPN in the gym locker room. I toss my bag in my locker and immediately escape to the pure, perfect, custom designed peace of my iPod’s audio world. I also well remember the glorious day I moved away from the hopelessness of my roommate’s awful sub-human, sub-slum stench and into my own private apartment. The universe changed miraculously overnight. I think you can get my drift. The simple act of moving itself can be powerfully transformational. Sometimes, there is not enough bleach and not enough distance between the walls to have the desired effect. Physically moving is quite often the only answer.

As we consider transhumanist societies, such transitional power is certainly the result by many magnitudes. My team has been engaged in developing the first permanent human undersea settlement over the past few decades. In this process we have had the distinct advantage of planning profoundly transhumanist advances specifically because of the advantageous context of relative community isolation. Further we have the benefit of deriving change as a community necessity — as a psychological and cultural imperative for this degree of advanced cultural evolution. It is a real kind of powerfully driven societal punctuated equilibrium that can be realized in few other ways.

In moving into the oceans, the submarine environment itself immediately establishes the boundary between the new, evolving culture and the old. While the effect and actual meaning of this boundary is almost always overrated, it is nonetheless a real boundary layer that allows the new culture to flourish sans the interferences or contamination from the old. Trying to accomplish transhumanist goals while culturally embedded is far more difficult and far less persuasive to those who must undergo dramatic change and for the transformation to actually take hold and survive generationally. But in a new, rather isolated environment, the pressure to evolve and integrate permanent change is not only easier, it is rather expected as a part of the reasonable process of establishment.

Continue reading “The Power of the Move Outbound” »

Transhumanism is all about the creative and ethical use of technology to better the human condition. Futurists, when discussing topics related to transhumanism, tend to look at nano-tech, bio-mechanical augmentation and related technology that, for the most part, is beyond the comprehension of lay-people.

If Transhumanism as a movement is to succeed, we have to explain it’s goals and benefits to humanity by addressing the common-man. After all, transhumanism is not the exclusive domain, nor restricted to the literati, academia or the rich. The more the common man realizes that (s)he is indeed already transhuman in a way — the lesser the taboo associated with the movement and the faster the law of accelerating returns will kick in, leading to eventual Tech Singularity.

Continue reading “4 ways Google Glass makes us Transhuman” »

A widely accepted definition of Transhumanism is: The ethical use of all kinds of technology for the betterment of the human condition.

This all encompassing summation is a good start as an elevator pitch to laypersons, were they to ask for an explanation. Practitioners and contributors to the movement, of course, know how to branch this out into specific streams: science, philosophy, politics and more.

- This article was originally published on ImmortalLife.info

Continue reading “Dirrogate Singularity — A Transhumanism Journey” »

Of the two images above, as a typical Science Fiction reader, which would you gravitate towards? In designing the cover for my book I ran about 80 iterations of 14 unique designs through a group of beta readers, and the majority chose the one with the Green tint. (design credit: Dmggzz)

No one could come up with a satisfying reason on why they preferred it over the other, except that it “looked more sci-fi” I settled for the design on the right, though it was a very hard decision to make. I was throwing away one of the biggest draws to a book — An inviting Dystopian book cover.

As an Author (and not a scientist) myself, I’ve noticed that scifi readers seem to want dystopian fiction –exclusively. A quick glance at reader preferences in scifi on sites such as GoodReads shows this. Yet, from noticing Vampire themed fiction rule the best seller lists, and from box office blockbusters, we can assume, the common man and woman is also intrigued by Longevity and Immortality.

Continue reading “Why does Science Fiction gravitate towards Dystopia and not the Utopia that Transhumanism promises?” »

Medical science has changed humanity. It changed what it means to be human, what it means to live a human life. So many of us reading this (and at least one person writing it) owe their lives to medical advances, without which we would have died.

Live expectancy is now well over double what it was for the Medieval Briton, and knocking hard on triple’s door.

What for the future? Extreme life extension is no more inherently ridiculous than human flight or the ability to speak to a person on the other side of the world. Science isn’t magic – and ageing has proven to be a very knotty problem – but science has overcome knotty problems before.

A genuine way to eliminate or severely curtail the influence of ageing on the human body is not in any sense inherently ridiculous. It is, in practice, extremely difficult, but difficult has a tendency to fall before the march of progress. So let us consider what implications a true and seismic advance in this area would have on the nature of human life.

Continue reading “Who Wants To Live Forever?” »