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FactorBioscience Announces U.S. Department of Defense Grant to Develop Gene-Edited Cell Therapies Read the latest here.

Factor Bioscience Inc. announced the award of a U.S. Department of Defense grant to develop next-generation cell therapy candidates using Factor’s patented mRNA, cell-reprogramming, and gene-editing technologies. The project will be led by Factor’s Co-Founder and Chief Technology Officer, Dr. Christopher Rohde.

Under the award, Factor will generate the first scalable cell therapy specifically targeting muscle inflammation in DMD patients. To carry out the work, Factor will utilize its extensively patented technologies for engineering cells, including methods for reprogramming and gene-editing cells using mRNA.

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Researchers who have been working for years to understand electron arrangement, or topology, and magnetism in certain semimetals have been frustrated by the fact that the materials only display magnetic properties if they are cooled to just a few degrees above absolute zero.

A new MIT study led by Mingda Li, associate professor of nuclear science and engineering, and co-authored by Nathan Drucker, a graduate research assistant in MIT’s Quantum Measurement Group and PhD student in applied physics at Harvard University, along with Thanh Nguyen and Phum Siriviboon, MIT graduate students working in the Quantum Measurement Group, is challenging that conventional wisdom.

The open-access research, published in Nature Communications, for the first time shows evidence that topology can stabilize magnetic ordering, even well above the magnetic transition temperature — the point at which magnetism normally breaks down.

Li-fi, a communication technology harnessing visible light for data transmission, has a potential to surpass Wi-Fi’s speed by more than 100 times and boasts a high bandwidth, facilitating the simultaneous transmission of copious information. Notably, Li-fi ensures robust security by exclusively transmitting data to areas illuminated by light.

Most important, it capitalizes on existing indoor lighting infrastructure, such as LEDs, eliminating the need for separate installations. However, implementing visible light communication (VLC) in practical lighting systems poses an issue of diminished stability and accuracy in data transmission.

Recently, a collaborative team led by Professor Dae Sung Chung, from the Department of Chemical Engineering at Pohang University of Science and Technology (POSTECH), with researcher Dowan Kim, Professor Dong-Woo Jee and Hyung-Jun Park from the Department of Intelligence Semiconductor Engineering at Ajou University, and Professor Jeong-Hwan Lee from the Department of Materials Science and Engineering at Inha University, succeeded in utilizing indoor lighting for wireless communication by reducing light interference with a novel light source. Their findings were published in Advanced Materials.

Space coiling acoustic metamaterials are static and require manual reconfiguration for sound-field modulation. In a new report published in Communications Materials, Christabel Choi, and a team of scientists in computer science and engineering in the U.K., and Italy, developed an approach for active reconfiguration with standalone dynamics to space-coil unit cells known as dynamic meta-bricks.

The meta-bricks housed an actuatable, magnetorheological, elastomeric flap, to function like a switch and to directly regulate the transmitted ultrasound. The scientists showed the synergy between active and passive reconfigurability to develop multifunctional metamaterials with additional degrees of freedom, for design and implementation.

Producing photons one at a time on demand at room temperature is a key requirement for the rollout of a quantum internet—and the practical quantum computers that would undergird that network. The photons can be used as quantum bits (qubits), the quantum equivalent of classical computing’s 0s and 1s. Labs around the world have devised various ways to generate single photons, but they can involve complex engineering techniques such as doped carbon nanotubes or costly cryogenically-cooled conditions. On the other hand, less complicated techniques such as using traditional light sources do not provide the necessary level of control over single-photon emissions required for quantum networks and computers.

Now, researchers from Tokyo University of Science (TUS) and the Okinawa Institute of Science and Technology have collaborated to develop a prototype room temperature single-photon light source using standard materials and methods. The team described the fabrication of the prototype and its results in a recent issue of the journal Physical Review Applied.

“Our single-photon light source … increases the potential to create quantum networks—a quantum internet—that are cost-effective and accessible.” —Kaoru Sanaka, Tokyo University of Science.

In fields such as physics and engineering, partial differential equations (PDEs) are used to model complex physical processes to generate insight into how some of the most complicated physical and natural systems in the world function.

To solve these difficult equations, researchers use high-fidelity numerical solvers, which can be very time consuming and computationally expensive to run. The current simplified alternative, data-driven surrogate models, compute the goal property of a solution to PDEs rather than the whole solution. Those are trained on a set of data that has been generated by the high-fidelity solver, to predict the output of the PDEs for new inputs. This is data-intensive and expensive because complex physical systems require a large number of simulations to generate enough data.

In a new paper, “Physics-enhanced deep surrogates for partial differential equations,” published in December in Nature Machine Intelligence, a new method is proposed for developing data-driven surrogate models for complex physical systems in such fields as mechanics, optics, thermal transport, fluid dynamics, physical chemistry, and climate models.

Textile research has highlighted the advances in electroluminescent threads as suitable biomaterials for driving growth in the wearable electronics market. While the direct embroidery of textiles with custom designs and patterns can offer substantial benefits, machine embroidery can challenge the integrity of these threads.

In a new report of applied science and engineering published in Science Advances, Seungse Cho and a team of scientists in biomedical engineering and medicine in the U.S., present embroiderable, multicolor, electroluminescent threads in blue, green, and yellow, that show compatibility with standard embroidery methods.

The researchers used the threads to stitch decorative designs onto a variety of consumer fabrics, without compromising their wearability or light-emitting capacity. The scientists illuminated specific messages or designs on the consumer products for the purpose of developing emergency alerts on helmet liners and as physical hazard signs.

As climate change continues to ravage the planet, coastal cities are at the highest risk due to coastal flooding attributed to sea level rise. According to the National Oceanic and Atmospheric Administration, approximately 127 million people in the United States alone live in coastal counties, or almost 40 percent of the entire population. Therefore, steps to protect coastal communities are of the utmost importance to mitigate the long-term impacts of climate change.

Strengthening coastal defenses from rising seas levels is what a groundbreaking study known as the PIONEER project, which is funded by the Engineering and Physical Sciences Research Council, hopes to address as scientists estimate coastal sea levels in the United States will experience the same sea level rise by 2050 that was experienced between 1920 and 2020, between 0.82 to 0.98 inches (0.25 to 0.30 meters).

“This is an interesting study because it combines, probably for the first time, the interactions for the effect of the water flooding on soils and, subsequently, on shoreline protective structures,” said Dr. Sherif Abdelaziz, who is an associate professor in the Charles E. Via, Jr. Department of Civil and Environmental Engineering, and one of many collaborators on the PIONEER project. “We will be able to assess how all these factors interact together so we can better design our shoreline protective structures to sustain the increasing intensity of waves and floods.”

The work demonstrates control over key properties leading to better performance.

MIT researchers and colleagues have demonstrated a way to precisely control the size, composition, and other properties of nanoparticles key to the reactions involved in a variety of clean energy and environmental technologies. They did so by leveraging ion irradiation, a technique in which beams of charged particles bombard a material.

They went on to show that nanoparticles created this way have superior performance over their conventionally made counterparts.