Lifeboat Foundation

Menthol detection predates the sensation of cold, indicating separate activation mechanisms that can be distinguished. This differentiation opens possibilities for novel pain treatments that avoid unwanted thermal side effects.

Millions of people around the globe suffer from chronic pain, and many existing treatments depend on opioids, which have significant addiction and overdose risks. Developing non-addictive pain relief options could transform how pain is managed. Recent research focusing on a human protein that controls cold sensations are paving the way for new pain medications. These innovative drugs aim to manage pain without altering body temperature or posing addiction risks.

A new study published in Science Advances on June 21, led by Wade Van Horn, professor in Arizona State University’s School of Molecular Sciences and Biodesign Center for Personalized Diagnostics, has uncovered new insights into the main human cold and menthol sensor TRPM8 (transient receptor potential melastatin 8). Using techniques from many fields like biochemistry and biophysics, their study revealed that it was a chemical sensor before it became a cold temperature sensor.

Scientists in Japan say they have reversed the signs of Alzheimer’s disease in lab mice by restoring the healthy function of synapses, critical parts of neurons that shoot chemical messages to other neurons.

The secret was developing a synthetic peptide, a small package of amino acids — a mini-protein, if you will — and injecting it up the nostrils of the mice, in an experiment they detailed in a study published in the journal Brain Research.

Needless to say, mice are very different from humans. But if the treatment successfully survives the gauntlet of clinical studies with human participants, it could potentially lead to a new treatment for Alzheimer’s disease, a tragic degenerative condition that burdens tens of millions of people around the world.

A series of advances in materials and design have enabled manufacturers to work at scales smaller than a billionth of a size to create devices and objects of nanoscopic dimensions. This is nanotechnology, which, although relatively new, produces materials and technologies already used in mass production.

The European Commission defines nano as any material that is at least 50% composed of particles between one and one hundred nanometers in size (i.e. one billionth of a meter, or one-millionth of a millimeter). Nanomaterials differ from conventional materials because of their unique properties such as higher electrical conductivity and mechanical strength, sensor technologies, and biomedical applications, and because they can create coatings that make surfaces more hydrophobic or self-cleaning.

The widespread use of nanotechnology is relatively new. Since 2000, nanomaterials have been used industrially as new research and experimental designs have made their effectiveness in different sectors clear. For example, in the health field, nanotechnology helps to reduce diagnostic errors and to develop nanobots (microscale robots) to repair and replace intercellular structures, or repair DNA molecules; in the chemical sector, it facilitates coating devices with nanoparticles to improve their smoothness and heat resistance; in manufacturing, materials developed with nanotechnology enhance the performance of the final product by improving heat resistance, strength, durability, and electrical conductivity.

Imagine a close basketball game that comes down to the final shot. The probability of the ball going through the hoop might be fairly low, but it would dramatically increase if the player were afforded the opportunity to shoot it over and over.

A similar idea is at play in the scientific field of membrane separations, a key process central to industries that include everything from biotechnology to petrochemicals to water treatment to food and beverage.

“Separations lie at the heart of so many of the products we use in our everyday lives,” said Seth Darling, head of the Advanced Materials for Energy Water Systems (AMEWS) Center at the U.S. Department of Energy’s (DOE) Argonne National Laboratory. “Membranes are the key to achieving efficient separations.”

Researchers at the National Graphene Institute have made a groundbreaking discovery that could revolutionise energy harnessing and information computing. Their study, published in Nature (“Control of proton transport and hydrogenation in double-gated graphene”), reveals how electric field effects can selectively accelerate coupled electrochemical processes in graphene.

Electrochemical processes are essential in renewable energy technologies like batteries, fuel cells, and electrolysers. However, their efficiency is often hindered by slow reactions and unwanted side effects. Traditional approaches have focused on new materials, yet significant challenges remain.

The Manchester team, led by Dr Marcelo Lozada-Hidalgo, has taken a novel approach. They have successfully decoupled the inseparable link between charge and electric field within graphene electrodes, enabling unprecedented control over electrochemical processes in this material. The breakthrough challenges previous assumptions and opens new avenues for energy technologies.

A new method in spectromicroscopy significantly improves the study of chemical reactions at the nanoscale, both on surfaces and inside layered materials. Scanning X-ray microscopy (SXM) at MAXYMUS beamline of BESSY II enables the investigation of chemical species adsorbed on the top layer (surface) or intercalated within the MXene electrode (bulk) with high chemical sensitivity. The method was developed by a HZB team led by Dr. Tristan Petit. The scientists demonstrated among others first SXM on MXene flakes, a material used as electrode in lithium-ion batteries.

Since their discovery in 2011, MXenes have gathered significant scientific interest due to their versatile tunable properties and diverse applications, from energy storage to electromagnetic shielding. Researchers have been working to decipher the complex chemistry of MXenes at the nanoscale.

The team of Dr. Tristan Petit now made a significant progress in MXene characterization, as described in their recent publication (Small Methods, “Nanoscale surface and bulk electronic properties of Ti 3 C 2 Tx MXene unraveled by multimodal X-ray spectromicroscopy”). They utilized SXM to investigate the chemical bonding of Ti 3 C 2 Tx MXenes, with Tx denoting the terminations (Tx=O, OH, F, Cl), with high spatial and spectral resolution. The novelty in this work is to combine simultaneously two detection modes, transmission and electron yield, enabling different probing depths.

Imagine if your dead laptop or phone could charge in a minute or if an electric car could be fully powered in 10 minutes. While not possible yet, new research by a team of CU Boulder scientists could potentially lead to such advances.

Published today in the Proceedings of the National Academy of Sciences, researchers in Ankur Gupta’s lab discovered how ions, move within a complex network of minuscule pores. The breakthrough could lead to the development of more efficient energy storage devices, such as supercapacitors, said Gupta, an assistant professor of chemical and biological engineering.

“Given the critical role of energy in the future of the planet, I felt inspired to apply my chemical engineering knowledge to advancing energy storage devices,” Gupta said. “It felt like the topic was somewhat underexplored and, as such, the perfect opportunity.”

Researchers discovered that bismuth atoms embedded in calcium oxide can function as qubits for quantum computers, providing a low-noise, durable, and inexpensive alternative to current materials. This groundbreaking study highlights its potential to transform quantum computing and telecommunications.

Calcium oxide is an inexpensive, chalky chemical compound frequently used in the manufacturing of cement, plaster, paper, and steel. However, the common material may soon have a more high-tech application.

Scientists used theoretical and computational approaches to discover how tiny, lone atoms of bismuth embedded within solid calcium oxide can act as qubits — the building blocks of quantum computers and quantum communication devices. These qubits were described by University of Chicago Pritzker School of Molecular Engineering researchers and their collaborator in Sweden on June 6 in the scientific journal Nature Communications.

Gene expression is inherently dynamic, due to complex regulation and stochastic biochemical events. Here the authors train a deep neural network to predict and dynamically control gene expression in thousands of individual bacteria in real-time which they then apply to control antibiotic resistance and study single-cell survival dynamics.