Lifeboat Foundation

For those curious about the Ukraine war which is involving over 75 countries (and the number keeps growing!):

Ukraine has received 41 powerful generators intended for health facilities from the Republic of Kazakhstan. Kazakhstan was occupied by Russian troops earlier this year so this is a big deal. Russia also does all their space launches from Kazakhstan.

The relevant statement was made by the Ukrainian Health Ministry on Facebook, an Ukrinform correspondent reports.

Continue reading “Ukraine receives 41 hospital generators from Kazakhstan” »

Transplanting a patient’s own hematopoietic stem cells may defer the progression of disability longer in patients with secondary progressive multiple sclerosis (SPMS) than treatment with other anti-inflammatory disease-modifying therapies (DMT), reports a study published in the journal Neurology “Hematopoietic Stem Cell Transplantation in People With Active Secondary Progressive Multiple Sclerosis”.

“Hematopoietic stem cell transplants have been previously found to delay disability in people with relapsing-remitting MS, but less is known about whether such transplants could help delay disability during the more advanced stage of the disease,” said Matilde Inglese, MD, PhD, professor of neurology at the University of Genoa in Italy and senior author of the study. “Our results are encouraging because while current treatments for SPMS have modest or small benefits, our study found stem cell transplants may not only delay disability longer than many other MS medications, they may also provide a slight improvement in symptoms.”

Patients initially diagnosed with relapsing-remitting MS, where periods of active flare-up of symptoms alternate spans of remission, eventually develop SPMS where the disease worsens gradually but steadily. The exact mechanisms leading to increased neurodegeneration in SPMS are unclear, but evidence suggests a major role of innate and adaptive immune mechanisms that drive inflammation in the brain parenchyma, the leptomeninges, and the cerebrospinal fluid.

Amid a surge in Covid-19 infections in China, US billionaire Elon Musk’s automotive company Tesla has reportedly suspended production at its Shanghai plant. The US automaker cancelled the morning shift on Saturday without mentioning a reason.

#tesla #shanghai #china.

Continue reading “China: Tesla halts production at Shanghai plant; year-end closure comes as Covid cases rise | WION” »

Astronauts are at higher risk for developing mutations—possibly linked to spaceflight—that can increase the risk of developing cancer and heart disease during their lifetimes, according to a first-of-its kind study from the Icahn School of Medicine at Mount Sinai.

Mount Sinai study could lead to ongoing health monitoring of astronauts to assess possible health risks and prevent disease progression.

Health — operanewsapp.

In the four years since an experiment by disgraced scientist He Jiankui resulted in the birth of the first babies with edited genes, numerous articles, books and international commissions have reflected on whether and how heritable genome editing—that is, modifying genes that will be passed on to the next generation—should proceed. They’ve reinforced an international consensus that it’s premature to proceed with heritable genome editing. Yet, concern remains that some individuals might buck that consensus and recklessly forge ahead—just as He Jiankui did.

An important breakthrough in understanding how inflammation is regulated has been made by scientists from Trinity College Dublin. They have just discovered that a key immune alarm protein previously believed to calm down the immune response actually does the opposite.

Their work has numerous potential impacts, especially in the context of understanding and responding to autoimmune disorders and inflammation.

Our immune system serves a very important function in protecting us from infection and injury. However, when immune responses become too aggressive this can lead to damaging inflammation, which occurs in conditions such as rheumatoid arthritis and psoriasis. Inflammation is triggered when our bodies produce “alarm proteins” (interleukins), which ramp up our defenses against infection and injury by switching on different components of our immune system.

A research group at Nagoya University in Japan has reported that a group of neurons, called EP3 neurons, in the preoptic area of the brain play a key role in regulating body temperature in mammals. The finding could pave the way for the development of a technology that artificially adjusts body temperature to help treat heat stroke, hypothermia, and even obesity. The new study was published in the journal Science Advances.

Body temperature in humans and many other mammals is regulated at about 37°C (98.6°F), which optimizes all regulatory functions. When body temperature noticeably deviates from the normal range, functions are impaired, which could lead to heat stroke, hypothermia, and, in the worst case, death. However, these conditions might be treated if body temperature can be artificially adjusted to the normal range.

The brain’s temperature regulation center resides in the preoptic area, a part of the hypothalamus that controls the body’s vital functions. For example, when the preoptic area receives signals from a mediator called prostaglandin E (PGE₂) that is produced in response to infections, this area releases a command to raise body temperature to fight against viruses, bacteria, and other disease-causing organisms.

The influenza virus is an recurring nightmare, killing thousands of people each year. Learn how the virus attacks its host, why it’s nearly impossible to eradicate, and what scientists are doing to combat it.
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