Lifeboat Foundation

Dedicated to ending the HIV epidemic — dr. moupali das, MD, MPH, executive director, HIV clinical research, gilead sciences.

Dr. Moupali Das, MD, MPH, is Executive Director, HIV Clinical Research, in the Virology Therapeutic Area, at Gilead Sciences (https://www.gilead.com/), where she leads the pre-exposure prophylaxis (PrEP) clinical drug development program, including evaluating the safety and efficacy of a long-acting, twice yearly, subcutaneous injection being studied for HIV prevention. Her responsibilities also include expanding the populations who may benefit from PrEP.

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National University of Singapore (NUS) pharmaceutical scientists have developed synthetic peptide nanonets for treating infections by bacteria strains resistant to last-resort antibiotics.

In nature, trap-and-kill is a common immune defense mechanism employed by various species, including humans. In response to the presence of pathogens, peptides are released from host cells and they promptly self-assemble in solution to form cross-linked nanonets, which then entrap the bacteria and render them more vulnerable to antimicrobial components.

Several research groups have explored synthetic biomimetics of nanonets as an avenue for addressing the global healthcare challenge of widespread antibiotic resistance. However, most prominent studies in the field only yielded disjointed short nanofibrils restricted to the bacterial surfaces and are incapable of physically immobilizing the bacteria. Additionally, these designs were lacking in control over the initiation of the self-assembly process.

Biophysical Therapeutics, a drug discovery platform company that leverages computational biology, has emerged from stealth. The primary targets of the Delaware-based company are cancer, the diseases of aging (including Alzheimer’s disease) and – excitingly – aging itself.

Founded by Dr Michael Forrest, a Cambridge University biochemistry graduate with a PhD in computer science, Biophysical Therapeutics boasts renowned biotech entrepreneur Professor George Church (of Harvard Medical School) as an advisor to the company. Professor Bruno Conti of the Scripps Institute in La Jolla, California is also an advisor.

Longevity. Technology: Back in 2006, Conti and his team reported an exciting result in the prestigious journal Science. They showed (in female mice) that slightly reducing the metabolic rate by slightly reducing metabolic heat generation (decreasing body temperature by 0.34°C) increased lifespan by 20%.

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In this Ask Me Anything interview, Prof. Matt Kaeberlein discusses the evidence (and lack thereof) behind popular anti-aging supplements and interventions. Starting from his current research on rapamycin for healthy longevity in dogs (The Dog Aging Project), he describes the promises and perils of anti-aging medicine and shares with us some tips on how to become better critical thinkers and protect us from hype and snake oil.

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Because it CAN be done does not mean it SHOULD be done.

We humans have not yet developed a strong understanding of unintended consequences.

Human neurons can survive — and even develop — after being transplanted into newborn rats. But are they still rats?

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It’s a morning routine familiar for many of us: Get that mouth clean immediately after breakfast by using a harsh toothpaste applied by an abrasive toothbrush, followed by a rinse with a mouthwash so strong it makes you wince. Dr. Kami Hoss winces, too, when he hears patients describe these habits.

Rational Virology Research For Human Health & Pandemic Prevention — Dr. Felicia Goodrum Sterling, Ph.D. Professor, Department of Immunobiology, The University of Arizona.

Dr. Felicia Goodrum, Ph.D. (https://profiles.arizona.edu/person/fgoodrum) is Interim Associate Department Head and Professor of Immunobiology, as well as Professor, BIO5 Institute, Cellular and Molecular Medicine, Molecular and Cellular Biology, Cancer Biology And Genetics Graduate Interdisciplinary Programs, at the University of Arizona.

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There’s an excessive amount of innovation embedded in right now’s cutting-edge pc chips, however not a lot of it’s as out-of-the-box because the considering that’s driving Australian startup Cortical Labs. The corporate, like so many startups with synthetic intelligence in thoughts, is constructing pc chips that borrow their neural community inspiration from the organic mind. The distinction? Cortical is utilizing precise organic neurons, taken from mice and people, to make their chips.

“We’re constructing the primary hybrid pc chip which entails implanting organic neurons on silicon chips,” Hon Weng Chong, CEO and co-founder of Cortical Labs, informed Digital Tendencies.

That is completed by first extracting neurons in two other ways, both from a mouse embryo or by remodeling human pores and skin cells again into stem cells and inducing these to develop into human neurons.

Low-cost robots that perfectly mimic parts of the human body foreshadow a future in which humanoid robots do all the work people don’t want.