Lifeboat Foundation

Retro Biosciences’ mysterious backer has finally been revealed!

In 2021 the longevity industry received one of its largest investments to date, with a $180m investment being made into the pharmaceutical start known as Retro Biosciences, or Retro Bio for short. Not only was this investment cause for celebration within the field of regenerative medicine, but it also came with a tantalising mystery, as the backer, or indeed backer, did not make themselves publicly known. It was assumed that due to the secrecy involved, it was likely that this investment had come from a small number of individuals, potentially just a single backer. This mystery backer, combined with the notable capital investment, led to much media attention at the time, and has since garnered a significant amount of interest in Retro Bio from both the general public and future potential financial backers. That was until last week, when the mystery backer finally decided that now was the right time to reveal their identity to the general public.

In an interview with MIT Technology review, American entrepreneur Sam Altman revealed that he was the sole backer for the pharmaceutical start-up, who single handily provided the entire $180m investment. Sam Altman, who primarily made his fortune in the tech industry (specifically through social media companies such as Loopt) has become somewhat of an angel investor for a slew of world changing, innovative companies which are involved in everything from artificial intelligence to nuclear energy. It is hoped that this significant single investment marks the beginning of a longevity tech boom, similar to what was seen during the dot-com boom (but hopefully without the disastrous ending).

The thyroid is a small, butterfly-shaped gland at the base of the neck. It’s responsible for the hormones that control your heart rate, blood pressure, temperature and metabolism.

When thyroid cells grow abnormally, they can cause thyroid cancer. But because symptoms are vague and may mimic other less-serious conditions, it’s possible you could have thyroid cancer for months or even years without knowing it.

Thyroid cancer surgeon Nancy Perrier, M.D., explains how thyroid cancer can go unnoticed – and what you can do to catch it early when it’s easiest to treat.

The potential for supply constraints also concerns industry analysts. For example, McKinsey analysts have warned that limited AAV vector capacity could delay the commercialization of new gene therapies, particularly those intended for larger patient populations.

Last March, a McKinsey article stated, “The majority of early viral-vector-based therapeutics were developed within the context of rare diseases. [Only small] quantities of viral vectors were required, particularly as most therapies were still in the clinical stage of development. Now, with the shift beyond ultrarare indications, viral vector manufacturing requires rapid expansion to be able to address these diseases in the commercial space.”

The Last of Us may be more real than you think. The spread of fungal pathogens in humans and other species are a disaster waiting to happen.

The sense of touch may soon be added to the virtual gaming experience, thanks to an ultrathin wireless patch that sticks to the palm of the hand. The patch simulates tactile sensations by delivering electronic stimuli to different parts of the hand in a way that is individualized to each person’s skin.

Developed by researchers at City University of Hong Kong (CityU) with collaborators and described in the journal Nature Machine Intelligence (“Encoding of tactile information in hand via skin-integrated wireless haptic interface”), the patch has implications beyond virtual gaming, as it could also be used for robotics surgery and in prosthetic sensing and control.

‘Haptic’ gloves, that simulate the sense of touch, already exist but are bulky and wired, hindering the immersive experience in virtual and augmented reality settings. To improve the experience, researchers led by CityU biomedical engineer Yu Xinge developed an advanced, wireless, haptic interface system called ‘WeTac’.

A group led by Professor Ralf Rabus, a microbiologist at the University of Oldenburg, and his Ph.D. student Patrick Becker has made significant advancements in comprehending the cellular processes of a widespread environmental bacterium. The team conducted an extensive analysis of the entire metabolic network of the bacterial strain Aromatoleum aromaticum EbN1^T and utilized the findings to construct a metabolic model that allows them to forecast the growth of these microbes in various environmental conditions.

According to their report in the journal mSystems, the researchers uncovered surprising mechanisms that enable the bacteria to adjust to fluctuating environmental conditions. These results are crucial for the study of ecosystems, where the Aromatoleum strain, as a representative of a significant group of environmental bacteria, can act as a model organism. The findings could also have implications for the cleanup of contaminated sites and biotechnological applications.

The studied bacterial strain specializes in the utilization of organic substances that are difficult to break down and is generally found in soil and in aquatic sediments. The microbes thrive in a variety of conditions including oxygen, low-oxygen, and oxygen-free layers, and are also extremely versatile in terms of nutrient intake. They metabolize more than 40 different organic compounds including highly stable, naturally occurring substances such as components of lignin, the main structural material found in wood, and long-lived pollutants and components of petroleum.

Brain haemorrhage and brain cancer are major causes of death and disability worldwide. The brain is.

Protect your child from flu and its sometimes serious complications with a flu vaccine every fall. Flu vaccines can be life-saving for children.

Did peptides precede life on Earth? Should we be looking for their biosignatures on Mars?

If you think of DNA in correspondence terms, it writes instructions. RNA picks up the instructions and delivers them to a recipient in the cell. The instructions contain a recipe and what follows is the filling of it producing a protein molecule explicitly designed for the required task.

But before all of the above ever could have happened there had to be something with simpler chemistry. A research team at Rutgers University believes that what first emerged was probably a peptide containing the element nickel. They have named it Nickelback, not to be confused with a Canadian rock band of the same name. This Nickelback peptide consists of two bound nickel atoms which exhibit both stability and activity in terms of reacting with surrounding chemistry. Such a peptide is capable of redox reactions that transfer electrons from one chemical substance to another and is essential as the first stage on the way to life.

Continue reading “How Life First Started Here On Earth With A Peptide” »