Lifeboat Foundation

May people worry that infectious pathogens will become resistant to current first-line therapies like antibiotics. Bacteria and other infectious diseases evolve and change to meet the needs of their environment and overcome treatments like these. Cancer is a well-known case in which the tumor cells evolve and become resistant to immunotherapy and other targeted treatments. Cancer is a prime example, because it rapidly divides and the mechanism by which it progresses allows tumor cells to avoid or overcome therapies. However, bacterial diseases are also common infections that can rapidly evolve. The World Health Organization (WHO) has even warned against a time in which antibiotics will not work. If this were the case, minor illnesses such as the common cold, could become fatal. The worry of antibiotic resistance is partly the reason we get yearly vaccinations. The Center for Disease Control (CDC) best predicts which viral infections will persist in the following year. A multitude of data is included in this prediction including the following:

Influenza, or the “flu,” is a viral respiratory infection that commonly affects the nose, throat, and lungs. Some symptoms of flu infection include fever, muscle ache, headache, dry cough, shortness of breath, general malaise, and more. Most healthy people with active flu infections can fight off the infection with their immune systems, however, certain high-risk groups may be prone to developing complications, such as children under 2 years old, adults over 65 years old, those that are pregnant, those with weakened immune systems, those with chronic illnesses, and those with a body mass index of 40 or higher.

The influenza vaccine is a preventative vaccine that reduces the chances of a patient having severe complications from the virus. Even after preventative measures such as the influenza vaccine, some adults remain at high risk for hospitalization following an infection. That is where flu antiviral drugs come in; antiviral drugs are medications that assist your body in fighting viruses.

The most common antiviral for the flu is Tamiflu, generically known as oseltamivir. Oseltamivir is a neuraminidase inhibitor and was approved by the United States Food and Drug Administration in 1999. When oseltamivir is started within two days of flu symptoms and confirmed flu infection, it can shorten length of illness along with a decrease in overall symptoms. This is especially useful in high-risk populations who may be able to prevent a hospitalization after taking oseltamivir.

Importance Despite widespread use, summary evidence from prior meta-analyses has contradictory conclusions regarding whether oseltamivir decreases the risk of hospitalization when given to outpatients. Several large investigator-initiated randomized clinical trials have not yet been meta-analyzed.

Objective To assess the efficacy and safety of oseltamivir in preventing hospitalization among influenza-infected adult and adolescent outpatients.

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

Mark Zuckerberg isn’t particularly shy about copying a good idea when he sees one.

From cribbing Snapchat’s stories feature to cloning TikTok in the form of Instagram Reels, the Facebook co-founder has a long and well-documented history of being a copycat.

Zuckerberg’s latest not-quite-innovation comes in the form of Threads, an Instagram-based Twitter competitor.

Anuva Kakkar, the 23-year-old entrepreneur behind Tiggle, an Agra-based D2C organic hot chocolate brand, has come a long way in a very short period despite the ongoing COVID-19 pandemic. From selling cups of hot chocolate to commuters outside the DLF Phase-3 metro station in Gurugram to starting her brand of hot chocolate powder and selling over 2 lakh cups through 2021, it has been a mercurial rise.

Made of premium cocoa sourced from a 40-acre family-owned certified organic farm near Pollachi, Tamil Nadu, Tiggle today sells three ‘premium’ varieties of hot chocolate powder — Light Hot Chocolate Mix, Dark Hot Chocolate Mix and Jaggery Hot Chocolate Mix. So, how did this entrepreneur from Agra set up her venture in such a challenging time for commerce?

Many cancer cells carry too many or too few chromosomes, a condition known as aneuploidy. Scientists have known this for a very long time, but the impact of aneuploidy has been unclear. Researchers recently developed a computational tool that analyzed cells from thousands of cancer patients. This effort identified critical regions of chromosomes that can be harmful or beneficial to tumor cells when they are deleted or duplicated. The findings have been reported in Nature.

In this study, the investigators developed a method called BISCUT (Breakpoint Identification of Significant Cancer Undiscovered Targets), which located where major changes start and end in chromosomes. Regions that were often found were more likely to help cancer cells survive while less commonly found regions were associated with a lack of cancer cell growth or their death. For example, one-third of all cancer cells in The Cancer Cell Genome Atlas lack one arm of chromosome 8.

Dr. Ralph W. Moss and son Ben discuss the science behind the health benefits of chocolate and how this delightful indulgence, often considered a guilty pleasure, can play a vital role in our overall well being.

Program Notes:
For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com.

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Restoring And Extending The Capabilities Of The Human Brain — Dr. Behnaam Aazhang, Ph.D. — Director, Rice Neuroengineering Initiative, Rice University

Dr. Behnaam Aazhang, Ph.D. (https://aaz.rice.edu/) is the J.S. Abercrombie Professor, Electrical and Computer Engineering, and Director, Rice Neuroengineering Initiative (NEI — https://neuroengineering.rice.edu/), Rice University, where he has broad research interests including signal and data processing, information theory, dynamical systems, and their applications to neuro-engineering, with focus areas in (i) understanding neuronal circuits connectivity and the impact of learning on connectivity, (ii) developing minimally invasive and non-invasive real-time closed-loop stimulation of neuronal systems to mitigate disorders such as epilepsy, Parkinson, depression, obesity, and mild traumatic brain injury, (iii) developing a patient-specific multisite wireless monitoring and pacing system with temporal and spatial precision to restore the healthy function of a diseased heart, and (iv) developing algorithms to detect, predict, and prevent security breaches in cloud computing and storage systems.

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