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A large case-control study by international researchers at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan has found that people who carry certain genetic risk factors for gastric (stomach) cancer have a much greater risk if they have also been infected by the bacterium Helicobacter pylori. The study, published in The New England Journal of Medicine, could contribute to the development of tailored genomic medicine for treating stomach cancer.

Stomach cancer is the fourth leading cause of cancer death worldwide and has both environmental and genetic risk factors. Environmentally, infection by H. pylori increases the risk of stomach cancer. Because the virulence of H. pylori in East Asia is high, the incidence of stomach cancer is higher in countries like Japan. Genetically, while hereditary gene variation is why we have different colored eyes and are unique as individuals, sometimes gene variants are associated with the risk of disease. For example, individuals who carry a certain hereditary pathogenic variant of the CDH1 gene have an increased risk of gastric cancer.

Testing for the presence of pathogenic variants is now one of several measures being taken for cancer prevention, surveillance, and treatment selection. However, because large-scale, case-control studies are lacking, and because those that exist have not assessed how the risk for stomach cancer changes when pathogenic variants interact with environmental factors like H. pylori, it remains unclear what actual clinical measures can be taken. To address this issue, researchers therefore evaluated the risk of gastric cancer in a large case-control study of Japanese people, considering whether they were carriers of pathogenic variants and whether they had been infected by H. pylori.

Jennifer Garrison is an assistant professor at the Buck Institute for Research on Aging and also holds appointments in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco (UCSF) and the Davis School of Gerontology at the University of Southern California.

Over 321 books from 170 plus interviews over 5 years.
https://www.learningwithlowell.com/over-321-books-from-170-i…todidacts/

Continue reading “Dr. Jennifer Garrison: Reproductive longevity, Aging, R&D, funding — Learning with Lowell” »

Altered dystrophin expression was found in some tumors and recent studies identified a developmental onset of Duchenne muscular dystrophy (DMD). Given that embryogenesis and carcinogenesis share many mechanisms, we analyzed a broad spectrum of tumors to establish whether dystrophin alteration evokes related outcomes. Transcriptomic, proteomic, and mutation datasets from fifty tumor tissues and matching controls (10,894 samples) and 140 corresponding tumor cell lines were analyzed. Interestingly, dystrophin transcripts and protein expression were found widespread across healthy tissues and at housekeeping gene levels. In 80% of tumors, DMD expression was reduced due to transcriptional downregulation and not somatic mutations. The full-length transcript encoding Dp427 was decreased in 68% of tumors, while Dp71 variants showed variability of expression.

A killer plant fungus infected a human and caused flu-like symptoms in what researchers say is a world-first case.

Chondrostereum purpureum causes silver leaf disease in flora, most commonly in species of rose.

Spread by airborne spores, it is named such because it gradually turns leaves silver — and is often fatal.

Continue reading “Killer plant fungus Chondrostereum purpureum infects man in India in ‘world-first case’” »

Energy production in nature is the responsibility of mitochondria and chloroplasts, and is crucial for fabricating sustainable, synthetic cells in the lab. Mitochondria are “the powerhouses of the cell,” but are also one of the most complex intracellular components to replicate artificially.

In Biophysics Reviews, by AIP Publishing, researchers from Sogang University in South Korea and the Harbin Institute of Technology in China identified the most promising advancements and greatest challenges of artificial mitochondria and chloroplasts.

“If scientists can create artificial mitochondria and chloroplasts, we could potentially develop synthetic cells that can generate energy and synthesize molecules autonomously. This would pave the way for the creation of entirely new organisms or biomaterials,” author Kwanwoo Shin said.

In this weeks episode of The Futurists, cognitive scientist and AI researcher Ben Goertzel joins the hosts to talk the likely path to Artificial General Intelligence. Goertzel is the founder of SingularityNet, Chairman at OpenCog Foundation, and previously as the Chief Scientist at Hanson Robotics he helped create Sophia the robot. Goertzel is on a different level, get ready to step up. Follow @bengoertzel.

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Subscribe and listen to TheFuturists.com Podcast where hosts Brett King and Robert TerceK interview the worlds foremost super-forecasters, thought leaders, technologists, entrepreneurs and futurists building the world of tomorrow. Together we will explore how our world will radically change as AI, bioscience, energy, food and agriculture, computing, the metaverse, the space industry, crypto, resource management, supply chain and climate will reshape our world over the next 100 years. Join us on The Futurists and we will see you in the future!

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One can only hope.

A former Google engineer has just predicted that humans will achieve immortality in eight years, something more than likely considering that 86% of his 147 predictions have been correct.

Ray Kurzweil visited the YouTube channel Adagio, in a discussion on the expansion of genetics, nanotechnology and robotics, which he believes will lead to age-reversing ‘nanobots’.

Continue reading “Former Google engineer predicts humans will achieve immortality within eight years” »

The actor Bruce Willis was diagnosed with aphasia in April 2022—updated in February 2023 to frontotemporal dementia (FTD). Now, a major advancement is helping develop new treatments for some people with motor neuron diseases, including FTD and ALS, possibly including a nasal spray that could help prevent the genetic disease.

I dunno if anyone has seen this. As a former Linux user, I’ve been an Nvidia fan for a long time and now they’ve gone on from games and Bitcoin mining. Sorry if this is a double post. I’m on my way out the door for my mom’s Dr appointment. I always worry I’ll double post by accident.

NVIDIA’s Jensen Huang just announced a set of revolutionary new Artificial Intelligence Models and Partnerships at GTC 2023. NVIDIA has always been one of, if not the most important company in the AI Industry by creating the most powerful AI hardware to date. Among them the A100 and future H100 GPU’s which are powering GPT-4 from OpenAI, Midjourney and everyone else. This gives them a lot of power to jump into the AI race themselves and allows them to surpass and beat the currently best AI models from Large Language Models and Image Generation with software like Omniverse and Hardware like the DGX H100 Supercomputer and Grace CPU’s.
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TIMESTAMPS:
00:00 NVIDIA enters the AI Industry.
01:43 GTC 2023 Announcements.
04:48 How NVIDIA Beat Every Competitor at AI
07:40 Running High End AI Locally.
10:20 What is NVIDIA’s Future?
13:05 Accelerating Future.
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Technology is improving at an almost exponential rate. Robots are learning to walk & think, Brain Computer Interfaces are becoming commonplace, new Biotechnology is allowing for age reversal and Artificial Intelligence is starting to surpass humans in many areas. Follow FutureNET to always be up to date on what is happening in the world of Futuristic Technology and Documentaries about humanities past achievements.
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#nvidia #ai #gtc