Lifeboat Foundation

The biology of aging is traditionally studied in fast-living organisms such as mice, worms and fruit flies. Short-lived species certainly have a role to play in this field, but they are only the tip of the iceberg.

Within the natural ecosystem, organisms display a range of aging processes, most often accelerated aging, or gradual aging (in the case of humans), but also, a range of species with slow or even negligible aging, which is known as negligible senescence. Unlike humans, such species have a constant mortality rate for the duration of their lifespan, as well as a constant or even increasing fertility rate. The number of negligibly senescent species which we are currently aware of is likely to grow as more and more are studied and discovered, both in the wild and in the lab.

By studying the processes which give these creatures longer lifespans, there is the possibility that they could be recreated in humans in order to extend our own. How negligible senescence is achieved by each individual species varies, but here are five of the most common traits.

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ALZHEIMER’S could be passed between humans during routine operations including dental work, shocking new research suggests.

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Scientists in the United States said Tuesday they had created a tiny implant which, in mice for now, captures cancer cells spreading through the body.

Cells moving from the original cancer site to infect other organs in a stealthy process called metastasis are usually detected too late to save a patient’s life.

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This is awesome!

Watch this little girl unwrap her 3D printed prosthetic arm!

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A comic book about stem cells, covering basic concepts related to stem cells, their properties and possible uses. TEXT: João Ramalho-Santos; ART: André Caetano.

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And Can We Use Them To Improve Health and Longevity

Junk DNA may play a critical role in the creation of new DNA.

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In April 2015, a paper by Chinese scientists about their attempts to edit the DNA of a human embryo rocked the scientific world and set off a furious debate. Leading scientists warned that altering the human germ line without studying the consequences could have horrific consequences. Geneticists with good intentions could mistakenly engineer changes in DNA that generate dangerous mutations and cause painful deaths. Scientists — and countries — with less noble intentions could again try to build a race of superhumans.

Human DNA is, however, merely one of many commercial targets of ethical concern. The DNA of every single organism — every plant, every animal, every bacterium — is now fair game for genetic manipulation. We are entering an age of backyard synthetic biology that should worry everybody. And it is coming about because of CRISPRs: clustered regularly interspaced short palindromic repeats.

Discovered by scientists only a few years ago, CRISPRs are elements of an ancient system that protects bacteria and other single-celled organisms from viruses, acquiring immunity to them by incorporating genetic elements from the virus invaders. CRISPRs evolved over millions of years to trim pieces of genetic information from one genome and insert it into another. And this bacterial antiviral defense serves as an astonishingly cheap, simple, elegant way to quickly edit the DNA of any organism in the lab.

Continue reading “Gene Editing Is Now Cheap and Easy—and No One Is Prepared for the Consequences” »

Using a double layer of lipids facilitates assembly of DNA origami nanostructures, bringing us one step closer to future DNA nanomachines, as in this artist’s impression (credit: Kyoto University’s Institute for Integrated Cell-Material Sciences)

Kyoto University scientists in Japan have developed a method for creating larger 2-D self-assembling DNA origami nanostructures.

Current DNA origami methods can create extremely small two- and three-dimensional shapes that could be used as construction material to build nanodevices, such as nanomotors, in the future for targeted drug delivery inside the body, for example. KurzweilAI recently covered advanced methods developed by Brookhaven National Laboratory and Arizona State University’s Biodesign Institute.

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GDF 11 has been publicised as another fountain of youth molecule, but with contradictory findings, does it live up to the hype, or could it be potentially harmful? It could be a bit of both.

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