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Researchers believe they can control the microscopic ‘fish’ to deliver drugs inside humans where they’re needed.

In early 2016 University Professor of Applied Physics Stephen Arnold earned a patent for his system for finding the size of one or more individual particles (such as nanoparticles) in real time using a microsphere’s whispering gallery modes.

Arnold and his team at Tandon’s MicroParticle PhotoPhysics Laboratory for BioPhotonics (MP3L) had generated excitement throughout the scientific community in 2012, when they created an ultra-sensitive biosensor capable of identifying the smallest single virus particles in solution.

Their technique was a major advance in a series of experiments to devise a diagnostic method sensitive enough to detect and a single virus particle in a doctor’s office or field clinic, without the need for special assay preparations or conditions. Normally, such assessment required the virus to be measured in the vacuum environment of an electron microscope, which added time, complexity and considerable cost.

Continue reading “Whispering gallery-mode biosensors are worth shouting about” »

A good summary article about the MitoSENS AMA on Reddit Futurology yesterday.

Aubrey de Grey, who should need little introduction here, is cofounder of the SENS Research Foundation, while Matthew O’Connor leads the foundation’s in-house research efforts. O’Connor’s focus is on the allotopic expression of mitochondrial genes, the complicated form of gene therapy needed to copy versions of these genes from the vulnerable mitochondrial genome into the much more secure nuclear genome, but altered in such a way that the resulting proteins can find their way back to the mitochondria where they are needed. Earlier today de Grey and O’Connor stopped by /r/futurology at Reddit to answer questions on this and other SENS rejuvenation research initiatives. One of the many benefits brought by this modern age of near zero cost communication is the way in which the barrier between researchers, supporters, and the public at large has faded to the point of non-existence. Any interested party can in a few minutes find out who is working in any specific areas of interest and reach out with questions or offers of support. Any researcher can find out where the interested parties congregate to talk about their research and join in. That was science fiction just a few decades ago. The world moves at a fast pace.

Once allotopic expression of the thirteen crucial mitochondrial genes involved in oxidative phosphorylation is realized, undergoing this gene therapy will ensure that the accumulation of mitochondrial DNA damage that occurs over the years no longer contributes to degenerative aging as it does today. It will be an actual, working narrowly focused rejuvenation therapy. As an incidental benefit, this technology will also provide cures for a range of inherited mitochondrial diseases. This work has been underway both at the SENS Research Foundation and in allied labs for some years now, and the biotech company Gensight has been founded on success in allotopic expression of the gene ND4. The SENS Research Foundation in-house team recently achieved success for the mitochondrial genes ATP6 and ATP8, and had a paper accepted by a noted journal, which all in all is a great step forward in a field that has proven to be quite challenging.

Continue reading “Aubrey de Grey and Matthew O’Connor of the SENS Research Foundation Answer Questions on Mitochondrial Research at /r/futurology” »

SRF Summer scholar cited in nature article about the high costs of drug development and how we can reduce them.

In a pioneering move, the compound JQ1 was released to the community for free. The impact that this has had on research and development is slowly coming into focus.

The futurist says that we’re getting closer and closer to “reprogramming” the human body.

Self-stabilising wheelchair from Israeli technology start-up lets you cruise through town while standing. Matthew Stock reports.

Nearly 20 years ago Amit Goffer suffered an accident that confined him to a wheelchair. Increasingly dissatisfied with what was on offer, the electrical engineer built this — the UPnRIDE. It’s a robotic exoskeleton that helps people paralysed from the waist down to stand tall in the outside world. (SOUNDBITE) (English) CHIEF TECHNICAL OFFICER AND FOUNDER OF UPNRIDE, DOCTOR AMIT GOFFER SAYING: “The UPnRIDE device, the whole idea is that you can use it outdoors as well as indoors and in a safe manner because they, it automatically balances you and stablizes you… The concept is new because you don’t see any disabled person rolling outside in a standing position so this is a breakthrough in the industry of wheelchair manufacturing, I’m sure that others will follow.” It goes from seated to standing at the push of a button. A gyroscope — similar to that in a two-wheeled Segway — along with self-stabilising software helps manoeuvre upright over uneven urban terrain.

Amazing — fighting cancer with a new drug that self-assembles from individual cells that interact with each other into a complex structure through weak supramolecular interactions.

The first multicellular organism, Volvox, evolved from self-assembly of individual cells. Inspired by this organism, researchers from Brigham and Women’s Hospital have developed a novel approach for treating cancer. Drawing from the lessons of evolution, they designed anti-cancer molecules that can self-assemble with each other into a complex structure through weak supramolecular interactions. The complex, supramolecular therapeutics home into the tumor, increasing anticancer efficacy and reducing side effects.

To engineer the supramolecular therapeutics, the researchers developed a first-of-its-kind computational algorithm that simulates how anticancer molecules interact with each other at the molecular and atomic level. This understanding led to the design of the most optimal building blocks that can click with each other like LEGO blocks to form the supramolecular therapeutic. The researchers have named this computational algorithm Volvox after the biological organism.

Ashish Kulkarni, PhD, an instructor in the Division of Engineering in the Department of Medicine at the Brigham and Women’s Hospital, and the lead author of the paper published in September issue of ACS Nano, said, “The algorithm saves a lot of time during the development of next generation cancer therapy. Before we even go into experimental analysis, we are able to see whether or not there is a high enough concentration of the drug for the treatment to be effective. We hope that our method can eventually be used to treat many different types of cancer.”

Doctors have long dreamed of delivering drugs to specific parts of your body, and they may soon have a clever way to do it: fish. UC San Diego researchers have developed nanoscale metallic fish (they’re just 800 nanometers long) that could carry medicine into the deeper reaches of your bloodstream. Each critter has a gold head and tailfin, as well as a nickel body joined by silver hinges. You only have to subject them to an oscillating magnetic field to make them swim — there’s no need for propellers or a passive (read: slow) delivery system. That, in turn, could make the drug carriers smaller even as they move quickly.

The technology definitely has its flaws. It’s not currently biodegradable, so you may be stuck with this school of fish unless there’s a way to flush them out. Gold and silver aren’t the cheapest metals, either. Scientists are working on biodegradability, however, and they’re hopeful that it will be useful for more than just guiding drugs. You could use to control individual cells, for example, or conduct certain forms of non-invasive surgery. It may just be a matter of refining the technique before you can get medicine exactly where you need it.

Continue reading “Nano-sized metal fish deliver targeted drugs to your body” »

A team of researchers at Jadavpur University here has developed a biodegradable energy harvester from raw fish scales that could in future replace pacemaker devices for the heart.

The energy harvester thus could be tapped as a sustainable green power source for next generation self-powered implantable medical devices.

It also has the potential for personal portable electronics with reduced e-waste elements said the researchers.

Continue reading “Indian Scientists Recycle FIsh Bio-Waste Into Green Energy” »