Lifeboat Foundation

Expensive EpiPen auto-injectors dominate the market for emergency allergy treatment, but a cheaper alternative is now being developed: an epinephrine tablet that dissolves under the tongue.

Last month a congressional committee tore into Mylan CEO Heather Bresch. The charge: jacking up the price of EpiPens, her company’s signature product. Those price hikes left some allergy sufferers without access to emergency epinephrine, the drug that saves people who go into anaphylactic shock.

Mylan has control of the marketplace because other companies have a hard time competing with the EpiPen’s patented design. Those who have tried have mostly offered up alternative types of auto-injectors, which generally flop.

Continue reading “Forget The EpiPen—It’s Time For An Epi-Pill” »

Patently Apple’s other blog called Patently Mobile has covered the advances of flexible displays from Samsung for years. You could check out some of the major ones here: (one, two, three and four. The most interesting ones relate to a possible scrollable smart device. Today the US Patent & Trademark Office published a patent application from Apple that reveals their work on flexible displays and electronics that will extend to specialty applications. Beyond applying their revealed technology to known devices such as a smartphone or tablet, Apple see’s the technology being widely adopted into smart clothing, smart windows, applications in vehicles, furniture and more. One of the inventors on the patent previously worked for a company where they made flexible medical devices, skin-mounted epidermal electronics and even next gen flexible processors. So this is a serious invention that is likely to work through the system over time and eventually to market. It’s not just pie in the sky thinking.

Traditional displays and touch sensors mounted in a device may be subject to stress-induced failures. As devices with flexible displays are being considered for the future, Apple has to invent new and improved input-output methodologies to accommodate such displays.

Apple notes that their invention relates to a flexible input-output device such as a display or a display with integrated sensors and haptic output may be formed from an elastomeric substrate layer.

Continue reading “Apple Invents Flexible Displays and Electronics to Work with Future iDevices, Clothing, Smart Windows & more” »

Excellent read on study of Sirt1 in endothelium-dependent vascular function.

Sirtuin1 (Sirt1) is a class III histone deacetylase that regulates a variety of physiological processes, including endothelial function. Caveolin1 (Cav1) is also an important determinant of endothelial function.

Electromagnetic pulses lasting one millionth of a millionth of a second may hold the key to advances in medical imaging, communications and drug development. But the pulses, called terahertz waves, have long required elaborate and expensive equipment to use.

Now, researchers at Princeton University have drastically shrunk much of that equipment: moving from a tabletop setup with lasers and mirrors to a pair of microchips small enough to fit on a fingertip.

In two articles recently published in the IEEE Journal of Solid State Circuits, the researchers describe one microchip that can generate terahertz waves, and a second chip that can capture and read intricate details of these waves.

Everyone knows prevention is better than a cure, and that’s as true for law enforcement as it is for medicine. But there’s little evidence that a growing trend towards “predictive policing” is the answer, and it could even bake in racial bias.

Police departments faced with tight budgets are increasingly turning to machine learning-enabled software that can sift through crime data to help predict where crimes are likely to occur and who might commit them.

Using statistics in law enforcement is nothing new. A statistical system for tracking crime called Compstat was pioneered in New York in 1994 and quickly became popular elsewhere. Since then, crime has fallen 75 percent in New York, which has been credited by some to the technology. But while Compstat simply helped identify historical hotspots, “predictive policing” uses intelligent algorithms to forecast tomorrow’s hotspots and offenders.

Continue reading “Could Predictive Policing Lead to a Real-Life Minority Report?” »

A biopharmaceutical company focused on the development and commercialization of innovative therapeutics for disease intersections of arthritis, hypertension, and cancer, today announced that they have entered into a license agreement regarding the Company’s SMARTICLES platform for the delivery of nanoparticles including small molecules, peptides, proteins and biologics…

Marina Biotech, Inc. a biopharmaceutical company focused on the development and commercialization of innovative therapeutics for disease intersections of arthritis, hypertension, and cancer, today announced that they have entered into a license agreement regarding the Company’s SMARTICLES platform for the delivery of nanoparticles including small molecules, peptides, proteins and biologics. This represents the first time that the Company’s SMARTICLES technologies have been licensed in connection with nanoparticles delivering small molecules, peptides, proteins and biologics. Under terms of the agreement, Marina could receive up to $90MM in success based milestones. Further details of the agreement were not disclosed.

Nice.

Testing treatments for bone cancer tumors may get easier with new enhancements to sophisticated support structures that mimic their biological environment, according to Rice University scientists.

A team led by Rice bioengineer Antonios Mikos has enhanced its three-dimensional printed scaffold to see how Ewing’s sarcoma (bone cancer) cells respond to stimuli, especially shear stress, the force experienced by tumors as viscous fluid such as blood flows through bone. The researchers determined the structure of a scaffold, natural or not, has a very real effect on how cells express signaling proteins that help cancer grow.

Continue reading “Better 3D-printed scaffolds help scientists study cancer” »

Interesting read on recent Gastric Cancer research. I do a lot of work with the National Esophageal Cancer (EC) Awareness Association; I can tell you that this disease is truly a killer as gastric related cancers are horrible to detect early enough and have a horrible record of reoccurring. Survival rates are some of the worst and today the rates of EC have skyrocketed especially in the younger age groups such as 25 to 35 year olds.

When you work for these foundations, read the stories from patients and their families looking for answers and help with everything from help on what types of food can their love eat and hopefully keep down for nutrition, to how can they get help with transportation to simply go to work or the doctor as meds restrictions on driving, to knowing the end is near and how to prepare, etc. The worst ones are the 27 to 36 yr old fathers and mothers whose love one is saying good bye to the person they married only recently married the year before or spent 7 years with. This is why I work for my foundations as every small step does in the end create a larger impact in the end and hopefully helps us finally beat this disease.

STING (stimulator of interferon genes) has recently been found to play an important role in host defenses against virus and intracellular bacteria via the regulation of type-I IFN signaling and innate immunity. Chronic infection with Helicobacter pylori is identified as the strongest risk factor for gastric cancer. Thus, we aim to explore the function of STING signaling in the development of gastric cancer. Immunohistochemistry was used to detect STING expression in 217 gastric cancer patients who underwent surgical resection. STING protein expression was remarkably decreased in tumor tissues compared to non-tumor tissues, and low STING staining intensity was positively correlated with tumor size, tumor invasion depth, lymph mode metastasis, TNM stage, and reduced patients’ survival. Multivariate analysis identified STING as an independent prognostic factor, which could improve the predictive accuracy for overall survival when incorporated into TNM staging system. In vitro studies revealed that knock-down of STING promoted colony formation, viability, migration and invasion of gastric cancer cells, and also led to a defect in cytosolic DNA sensing. Besides, chronic H. pylori infection up-regulated STING expression and activated STING signaling in mice. In conclusion, STING was proposed as a novel independent prognostic factor and potential immunotherapeutic target for gastric cancer.

Need to share this with a few folks researching glaucoma disease and treatment/ mutation reversal.

Elderly are frequently hospitalized due to their age-associated organ degeneration, the presence of co-morbidities, and their susceptibility to adverse insults. Alterations in functional status often occur during hospitalization, and the degree of functional decline can parallel the severity of illnesses. For older persons, gauging their pre-morbid and in-hospital functional status facilitates treatment planning and potentially functional restoration^1,2,3. While the identification of risk factors or markers of poor pre-morbid and in-hospital functional status may help facilitate this process, this area remains under-researched to date. Factors associated with functional decline in the hospitalized elderly include the types of morbidities and the reasons for their admission. Indeed, elderly with chronic kidney disease (CKD) are more likely to exhibit functional decline, beginning from the earlier stage of CKD to end-stage renal disease (ESRD)^4,5; functional dependency also predisposes individuals with CKD and ESRD to recurrent hospitalization and higher mortality.

Albuminuria and proteinuria, as the staging criteria for CKD in the most recent version of Kidney Disease Improving Global Outcomes (KDIGO) CKD guidelines, are both well-established predictors of subsequent renal function decline. There is increasing awareness that albuminuria and proteinuria have an independent role in the prediction of adverse outcomes apart from the baseline renal function. As explained above, although CKD is associated with poor functional status, it is still unclear whether proteinuria alone exhibits similar association with functional status regardless of CKD. No reports focus on this association using the severity of proteinuria among geriatric patients with acute medical illnesses.

Continue reading “Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease” »