Lifeboat Foundation

Summary: Researchers unveiled a groundbreaking discovery that DNA damage and brain inflammation are vital processes for forming long-term memories, particularly within the brain’s hippocampus.

Contrary to previous beliefs associating inflammation with neurological diseases, this study highlights inflammation’s critical role in memory formation through the activation of the Toll-Like Receptor 9 (TLR9) pathway following DNA damage in hippocampal neurons.

These findings not only challenge conventional views on brain inflammation but also caution against indiscriminate inhibition of the TLR9 pathway, given its importance in memory encoding and the potential risks of genomic instability.

Groundbreaking research has led to the creation of threofuranosyl nucleic acid (TNA), offering enhanced stability and therapeutic potential, with applications in drug delivery and diagnostics.

The DNA carries the genetic information of all living organisms and consists of only four different building blocks, the nucleotides. Nucleotides are composed of three distinctive parts: a sugar molecule, a phosphate group, and one of the four nucleobases adenine, thymine, guanine, and cytosine. The nucleotides are lined up millions of times and form the DNA double helix, similar to a spiral staircase.

Breakthrough in Nucleic Acid Research.

A novel antibody therapy makes the immune system of old mice appear younger, allowing the animals to better fend off infections and reduce inflammation.

By Grace Wade

Would you wear this? Researchers just revealed a “spiral diopter” contact lens that has multiple focus points, allowing the user to to see clearly at multiple distances. Here’s what volunteers said when they tried it:

New spiral-shaped multifocal lenses bend light in a way that corrects problems seeing up close and far away, even in poor lighting.

March 27, 2024—(BRONX, NY)— Just as you can’t make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can’t make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.

“Inflammation of brain neurons is usually considered to be a bad thing, since it can lead to neurological problems such as Alzheimer’s and Parkinson’s disease,” said study leader Jelena Radulovic, M.D., Ph.D., professor in the Dominick P. Purpura Department of Neuroscience, professor of psychiatry and behavioral sciences, and the Sylvia and Robert S. Olnick Chair in Neuroscience at Einstein. “But our findings suggest that inflammation in certain neurons in the brain’s hippocampal region is essential for making long-lasting memories.”

The hippocampus has long been known as the brain’s memory center. Dr. Radulovic and her colleagues found that a stimulus sets off a cycle of DNA damage and repair within certain hippocampal neurons that leads to stable memory assemblies—clusters of brain cells that represent our past experiences. Elizabeth Wood, a Ph.D. student, and Ana Cicvaric, a postdoc in the Radulovic lab, were the study’s first authors at Einstein.

Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature of the aging process, little is known about the in vivo effects of senescent cells on intestinal fitness. Here, we identify the accumulation of senescent cells in the aging gut and, by harnessing senolytic CAR T cells to eliminate them, we uncover their detrimental impact on epithelial integrity and overall intestinal homeostasis in natural aging, injury and colitis. Ablation of intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged ISCs. This intervention improves epithelial integrity and mucosal immune function. Overall, these results highlight the ability of senolytic CAR T cells to rejuvenate the intestinal niche and demonstrate the potential of targeted cell therapies to promote tissue regeneration in aging organisms.

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Medical office procedure identifies key biomarker that may lead to more reliable diagnosis of neurodegenerative disorders.

Gert-Jan Oskam was living in China in 2011 when he was in a motorcycle accident that left him paralyzed from the hips down.

In a new study, researchers describe a device that connects the intentions of a paralyzed patient to his physical movements.

The legendary science fiction writer shares his thoughts on the future of medicine, communications and more.

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