Lifeboat Foundation

More than 2,000 papers have been published about the virus since December. It will take some smart algorithms to mine insights from them.

Patients with hypertension appear to be at a higher risk of dying from the coronavirus, said a top Chinese intensive care doctor who’s been treating critically ill patients since mid-January.

While there’s been no published research yet explaining why, Chinese doctors working in Wuhan, the central Chinese city where the virus first emerged, have noticed that infected patients with that underlying illness are more likely to slip into severe distress and die.

Of a group of 170 patients who died in January in Wuhan — the first wave of casualties caused by a pathogen that’s now raced around the world — nearly half had hypertension.

Imagine the following scenario. You are a doctor working in a hospital in a very large and relatively polluted city, normally subject to a high level of seasonal respiratory ailments. Moreover, your healthcare system is stretched because of budget cuts and the devolution policies of central government. As a medical doctor you also know that flu viruses routinely mutate and may even be transferred from animals to humans. Exactly how all this happens varies from year to year – as does the exact mortality rate, though the pattern of infection and mortality is relatively well understood. In all these cases, the vast majority of people remain uninfected, asymptomatic or subject to mild symptoms that pass within a week. However, if the number of those requiring intensive hospital-based treatment rises above a certain percentage, the healthcare system can be quickly challenged. At that point, the doctor may panic, and armed with social media, he can now spread his concern around the world. But is the sheer appearance of a new virus strain the overriding cause?

The only part of this story that is really new is the availability of social media to spread news about any outbreak of such flu-like diseases. But one should not underestimate a general background awareness of overstretched public healthcare systems around the world, due partly to an ageing population but mainly due to the neoliberal policy horizon. Actions like the initial Chinese response to suppress the ‘whistleblower’ Li Wenliang have happened at the start of previous outbreaks – but now whistleblowers can communicate directly with the world. It is easy to forget that various new strains of flu are routinely reported in the media each year, with greater or lesser morbidity than earlier ones. Governments around the world normally monitor the situation in their own way, which means that the real figures have probably always been much higher than officially stated – both who catches the flu and who dies from it. Much depends on the motivation of the national health authorities to test specifically for the flu’s presence. After all, flu typically operates as a ‘nudge’ to worsen existing health conditions, and those conditions may be the primary medical focus.

We clearly don’t know everything we need to know about COVID-19. But the same applied to all the previous flu epidemics, which humanity has so far managed to survive. What is different now is the level of scrutiny and accountability of the response, mostly due to the recent information technology revolution, especially social media. This very basic socio-technical point has made it easier for the World Health Organization to designate COVID-19 a pandemic. The WHO’s insistence on mass testing (even if it doesn’t catch those who have recovered) also fits the same logic. What is striking so far about the global response are the efforts that societies have taken to reorganize themselves in order to protect those who are perceived as most vulnerable. It is quite unprecedented, especially in a world that is so otherwise imbued with capitalist values.

In the end, COVID-19 is the first virus to go properly ‘viral’, starting with Li Wenliang. That start has anchored the subsequent response. In particular, it has triggered a chain reaction that has exposed the different cultures of risk management around the world, as well as the varying conditions of national health care systems. Think of it as Nature’s brute audit on humanity’s sustainability. Indeed, that may be the virus’ main direct legacy – which means that public health care is bound to improve all round in the long run. However, if the lockdown continues long enough, the virus may end up questioning the modus operandi of contemporary capitalism in a way that long-standing complaints about inequality have failed to do. I expect that the vast majority of the population will manage to cope reasonably well during our period of ‘species captivity’, while consuming significantly less of the planet’s resources – that is, assuming that the increasing energy demands of online activities don’t first cause a short-circuit!

Continue reading “When a Virus Goes Viral -- Life with COVID-19” »

Gilead’s antiviral medication remdesivir could radically change the course of the ongoing COVID-19 outbreak.

A new variation of the gene-editing technology CRISPR-Cas9 can correct mutations in the CFTR gene — the genetic cause of cystic fibrosis (CF) — in stem cells from CF patients, a study shows.

The new approach has the ability to correct mutations without the need to excise the affected region, the researchers said.

The study, “CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank,” was published in the journal Cell Stem Cell.

A team of Australian researchers say they’ve found a cure for the novel coronavirus and hope to have patients enrolled in a nationwide trial by the end of the month.

University of Queensland Centre for Clinical Research director Professor David Paterson told news.com.au today they have seen two drugs used to treat other conditions wipe out the virus in test tubes.

He said one of the medications, given to some of the first people to test positive for COVID-19 in Australia, had already resulted in “disappearance of the virus” and complete recovery from the infection.

Cleantech is usually focused on electric cars, batteries, clean electrical generation, and the like. But clean also has a more direct connotation for humans of being free from disease.

Danish company UVD Robotics makes germ-, virus-, and mold-killing ultraviolet robots for hospitals. The product has been in existence for a while, but now it’s signed contracts with Chinese hospitals and is shipping units to that country.

Chinese officials say they’ll have a coronavirus vaccine ready next month for emergency situations and clinical trials.

Eight institutes in the country are working on five approaches to inoculations in an effort to combat COVID-19, according to the South China Morning Post. The contagious illness has sickened more than 118,000 people and killed at least 4,200 worldwide, mostly in mainland China, as of Tuesday afternoon.

“According to our estimates, we are hopeful that in April some of the vaccines will enter clinical research or be of use in emergency situations,” Zheng Zhongwei, director of the National Health Commission’s Science and Technology Development Center, said Friday.

Erythropoietin, or Epo for short, is a notorious doping agent. It promotes the formation of red blood cells, leading thereby to enhanced physical performance — at least, that is what we have believed until now. However, as a growth factor, it also protects and regenerates nerve cells in the brain. Researchers at the Max Planck Institute of Experimental Medicine in Göttingen have now revealed how Epo achieves this effect. They have discovered that cognitive challenges trigger a slight oxygen deficit (termed ‘functional hypoxia’ by the researchers) in the brain’s nerve cells. This increases production of Epo and its receptors in the active nerve cells, stimulating neighbouring precursor cells to form new nerve cells and causing the nerve cells to connect to one another more effectively.

The growth factor erythropoietin is among others responsible for stimulating the production of red blood cells. In anaemia patients it promotes blood formation. It is also a highly potent substance used for illegal performance enhancement in sports.

“Administering Epo improves regeneration after a stroke (termed ‘neuroprotection’ or ‘neurogeneration’), reducing damage in the brain. Patients with mental health disorders such as schizophrenia, depression, bipolar disorder or multiple sclerosis who have been treated with Epo have shown a significant improvement in cognitive performance,” says Hannelore Ehrenreich of the Max Planck Institute of Experimental Medicine. Along with her colleagues, she has spent many years researching the role played by Epo in the brain.