Lifeboat Foundation

Undifferentiated human stem cells have been coaxed to develop into skin-like structures in vitro. When engrafted onto mice, the structures produce hair — highlighting the potential of the approach for regenerative therapies. Hair-follicle organoids that have a full complement of skin cells.

The discovery of the Dead Sea Scrolls had an incomparable impact on the historical understanding of Judaism and Christianity. ‘Piecing together’ scroll fragments is like solving jigsaw puzzles with an unknown number of missing parts. Because most of the 2,000-year-old scrolls were written on processed animal skin, an international team of researchers used DNA sequencing to ‘fingerprint’ fragments based on their genetic signature.

Scientists have found a new method to strategically add deuterium to benzene, an aromatic compound commonly found in crude oil. When applied to the active ingredient of drugs to incorporate deuterium, it could dramatically improve the drugs’ efficacy and safety and even introduce new medicines.

To validate the method, which was published in Nature, a team led by W. Dean Harman of the University of Virginia worked with Xiaoping Wang at the Oak Ridge National Laboratory’s Spallation Neutron Source. Wang successfully verified the exact position of deuterium atoms that resulted from the selective deuteration of benzene molecules using single crystal neutron diffraction.

“Because the high sensitivity of neutrons to hydrogen and its deuterium isotope, we were able to quantitatively assign not only the positions of the deuterium atoms at the atomic level, but also determine precisely how many were added on each side of the benzene molecule,” Wang said. “This is important in designing new therapeutic drugs.”

An underlying assumption of research on aging holds that dietary restriction (and drugs that mimic its effects) will slow aging to extend both lifespan and healthspan jointly. While eating a Spartan diet has been shown to robustly extend lifespan and delay age-related diseases in many species, a genome-wide analysis of 160 genetically distinct strains of the fruit fly D. melanogaster shows that lifespan and healthspan are not linked under dietary restriction. Results are published in Current Biology.

Though on average lifespan was extended and healthspan was increased, researchers from the Kapahi lab at the Buck Institute say the devil is in the details. In the study researchers measured nutrient-dependent changes in lifespan and tracked age-related changes in physical activity to measure healthspan. While 97 percent of strains showed some lifespan or healthspan extension in response to dietary restriction, only 50 percent of strains showed a significantly positive response to dietary restriction for both. Thirteen percent of the strains were more vigorous, yet died sooner with dietary restriction; 5 percent lived longer, but spent more time in poor health. The remaining 32 percent of the strains showed no benefits or detriments to lifespan or healthspan, or negative responses to both.

“Dietary restriction works, but may not be the panacea for those wanting to extend healthspan, delay age-related diseases, and extend lifespan,” said Pankaj Kapahi, Ph.D., Buck professor and senior author on the paper. “Our study is surprising and gives a glimpse into what’s likely going to happen in humans, because we’re all different and will likely respond differently to the effects of dietary restriction. Furthermore, our results question the idea that lifespan extension will always be accompanied by improvement of healthspan.”

A team of scientists from Stanford University is working with researchers at the Molecular Foundry, a nanoscience user facility located at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), to develop a gene-targeting, antiviral agent against COVID-19.

Last year, Stanley Qi, an assistant professor in the departments of bioengineering, and chemical and systems biology at Stanford University and his team had begun working on a technique called PAC-MAN—or Prophylactic Antiviral CRISPR in human cells —that uses the gene-editing tool CRISPR to fight influenza.

But that all changed in January, when news of the COVID-19 pandemic emerged. Qi and his team were suddenly confronted with a mysterious new virus for which no one had a clear solution. “So we thought, ‘Why don’t we try using our PAC-MAN technology to fight it?’” said Qi.

The pharmaceutical company aims to distribute 1 billion shots to people in low and middle income countries, with 400 million doses ready this year.

The cells fully integrated the genes that let squids turn translucent.

Polarization, the direction in which light vibrates, is invisible to the human eye. Yet, so much of our optical world relies on the control and manipulation of this hidden quality of light.

Materials that can manipulate the polarization of light —known as birefringent materials—are used in everything from digital alarm clocks to medical diagnostics, communications and astronomy.

Just as light’s polarization can vibrate along a straight line or an ellipse, materials can also be linearly or elliptically birefringent. Today, most birefringent materials are intrinsically linear, meaning they can only manipulate the polarization of light in a limited way. If you want to achieve broad polarization manipulation, you need to stack multiple birefringent materials on top of one another, making these devices bulky and inefficient.

Anders Tegnell says there was ‘potential for improvement’ in country’s strategy to fight pandemic.