Lifeboat Foundation

An incredibly focused study, led by researchers at the University of Virginia, has demonstrated the profound influence diet and gut bacteria has on the effectiveness and toxicity of drugs used in chemotherapy. Using a roundworm as a simplified microbiome model, the study showed how just one type of bacteria can exponentially increase a drug’s toxicity and the researchers conclude the complexity of drug, diet, and bacteria interactions in humans is “astronomical.”

A review article published last year in the journal Frontiers in Microbiology effectively summarized the current evidence supporting a hypothesis suggesting the gut microbiome plays a fundamental role in determining the efficacy of cancer chemotherapy. Recent research has shown how the pharmacological effects of a given drug can be directly influenced by bacteria in the gut, mediating a drug’s toxicity and efficacy.

Although a great deal of observational connections have been made between the gut microbiome and treatment outcomes for patients with a variety of diseases, this new study set out to zoom in on the underlying molecular processes at play.

Achieving near-zero friction in commercial and industrial applications will be game-changing from tiny microelectromechanical systems that will never wear out, to oil-free bearings in industrial equipment, to much more efficient engines and giant wind turbines scavenging energy even in low wind conditions. Superlubricity offers promising solutions to overcome lubrication challenges in various areas of nanotechnology including micro/nano-electromechanical systems (MEMS/NEMS), water transport control, biomedical engineering, atomic force microscopy (AFM), aerospace and wind energy applications, as well as other electronic devices. It is one of the most promising properties of functional nanomaterials for energy saving applications.

The European Union wants a massive dose of research spending to lift it out of what could be the worst recession in its history. Last week, as part of a €1.85 trillion budget and pandemic recovery proposal, the European Commission, the EU executive arm, unveiled plans to pump €94.4 billion into research over 7 years, nearly €11 billion more than originally planned for the program, called Horizon Europe. But not everyone thinks the money is the best medicine.

Horizon Europe gets €13.5 billion to spend fast, spur growth.

Neural networks have been taught to quickly read the surfaces of proteins — molecules critical to many biological processes. The advance is already being used to create defenses for the virus responsible for COVID-19.

Understanding the prebiotic origins of the nucleic acids is a long-standing challenge. The latest experiments support the idea that the first nucleic acid encoded information using a mixed ‘alphabet’ of RNA and DNA subunits. RNA and DNA nucleosides might have emerged together on prebiotic Earth.

In a paper published in the journal Thorax, a team of Australia researchers described the first instance of complete COVID-19 testing of all passengers and crew on an isolated cruise ship during the current pandemic: of the 217 passengers and crew on board, 128 tested positive for COVID-19 on reverse transcription-PCR; of the COVID-19-positive patients, only 24 (19%) were symptomatic.

Scientists have successfully transplanted functional miniature livers into rats, after growing the bioengineered organs in the lab from reprogrammed human skin cells.

The experiment, which gave the animals working liver organs, could lay the groundwork for future treatments to address terminal liver failure – a disease that claims the lives of over 40,000 people in the US every year.

While there’s still a lot of work to be done before the technique can directly aid human patients, the researchers say their proof of concept may help underpin a future alternative to liver transplants, which are often incredibly expensive procedures to perform, in addition to being strictly limited by donor supply.

Although promising, convalescent plasma has not yet been shown to be safe and effective as a treatment for COVID-19. Therefore, it is important to study the safety and efficacy of COVID-19 convalescent plasma in clinical trials.

Pathways for use of investigational COVID-19 convalescent plasma

The following pathways are available for administering or studying the use of COVID-19 convalescent plasma:

Immortalists magazine issue no. 5 is out smile

It is predicted that a pandemic of psychological and societal injuries is to come as we face financial and emotional crises across the globe.