Lifeboat Foundation

Before the first oncogene mutations were discovered in human cancer in the early 1980s, the 1970s provided the first data suggesting alterations in the genetic material of tumors. In this context, the prestigious journal Nature published in 1975 the existence of a specific alteration in the transformed cell: an RNA responsible for carrying an amino acid to build proteins (transfer RNA) was missing a piece, the enigmatic nucleotide ‘Y.’

After that outstanding observation, virtually no developments were made for forty-five years on the causes and consequences of not having the correct base in RNA.

In an article published in Proceedings of the National Academy of Sciences (PNAS) by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Professor of Genetics at the University of Barcelona has solved this mystery by observing that in cancer cells the protein that generates the nucleotide Y is epigenetically inactivated, causing small but highly aggressive tumors.

Populations of vampire bats are exploding and spreading deadly diseases.

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As one of the leaders in developing a COVID-19 vaccine, Moderna signed a contract worth up to $1.525 billion with the U.S. government to supply 100 million doses of mRNA-1273, the company’s experimental COVID-19 vaccine.

The agreement also includes incentive payments for hitting a production schedule. Moderna had a previous award of up to $955 million from BARDA for the development of the vaccine to licensure, which brings the U.S. government’s commitment for early access to the vaccine up to $2.48 billion. The U.S. government, as part of Operation Warp Speed, also can acquire another 400 million doses.

As part of this deal, the U.S. government says Americans will receive the vaccine at no cost. It is possible that healthcare professionals will charge for the cost of administering it.

Kate Broderick discusses the development of INOVIO’s frontrunner COVID-19 DNA vaccine and states the need for preparedness for future outbreaks.

The Space Force’s announcement last week that United Launch Alliance and SpaceX will launch expensive spy satellites and other military payloads brings a long and often fierce battle for government funds to an end — at least for now.

Why it matters: This type of government money — particularly in light of the economic downturn caused by the coronavirus pandemic — is key for space companies that often work on thin margins.

The state of play: ULA was awarded the bulk of the funds — $337 million — for two missions due to launch in 2022, with SpaceX winning $316 million for one mission launching that year.

(Credit: Anne Marthe Widvey/Flickr)

The finding may potentially make it easier to monitor people with sleep disorders, as well as unconscious coma patients or those under anesthesia.

Tesla’s Model 3 leads the EV sales in China with 11,014 vehicles sold in July. That’s more than the next 3 best-selling EVs combined!

In China this morning, the China Association of Automobile Manufacturers (CAAM) held a press conference in Beijing to update the public on the status of the automotive industry’s recovery.

Overall, it is good news for the market, which managed to recover from the global pandemic much quicker than the rest of the world.

Continue reading “Tesla still dominates electric car sales in China, over 11,000 deliveries in July” »

This video explains DNA packaging, structure of the nucleosome, and histone proteins.

The answer is in their genes—especially those that encode for basic life functions, such as metabolism. Thanks to the lowly C. elegans worm, we’ve uncovered genes and molecular pathways, such as insulin-like growth factor 1 (IGF-1) signaling that extends healthy longevity in yeast, flies, and mice (and maybe us). Too nerdy? Those pathways also inspired massive scientific and popular interest in metformin, hormones, intermittent fasting, and even the ketogenic diet. To restate: worms have inspired the search for our own fountain of youth.

Still, that’s just one success story. How relevant, exactly, are those genes for humans? We’re rather a freak of nature. Our aging process extends for years, during which we experience a slew of age-related disorders. Diabetes. Heart disease. Dementia. Surprisingly, many of these don’t ever occur in worms and other animals. Something is obviously amiss.

In this month’s Nature Metabolism, a global team of scientists argued that it’s high time we turn from worm to human. The key to human longevity, they say, lies in the genes of centenarians. These individuals not only live over 100 years, they also rarely suffer from common age-related diseases. That is, they’re healthy up to their last minute. If evolution was a scientist, then centenarians, and the rest of us, are two experimental groups in action.