Lifeboat Foundation

A newly discovered Alzheimer’s gene may drive the first appearance of amyloid plaques in the brain, according to a study led by researchers at Columbia University Irving Medical Center.

Some variants of the gene, RBFOX1, appear to increase the concentration of protein fragments that make up these plaques and may contribute to the breakdown of critical connections between neurons, another early sign of the disease.

The finding could lead to new therapies that prevent Alzheimer’s and better ways of identifying people with the greatest risk of developing the disease.

The virus SARS coronavirus 2 (SARS-CoV-2) is the known cause of coronavirus disease 2019 (COVID-19). The “spike” or S protein facilitates viral entry into host cells.

Now a group of researchers from Seoul National University in South Korea, University of Cambridge in UK, and Lehigh University in USA, have worked together to produce the first open-source all-atom models of a full-length S protein. The researchers say this is of particular importance because the S protein plays a central role in viral entry into cells, making it a main target for vaccine and antiviral drug development.

Continue reading “Scientists produce first open source all-atom models of COVID-19 ‘spike’ protein” »

Japanese machine can perform more than 415 quadrillion computations a second and has already worked out how breath droplets spread.

A Russian submarine passed through Turkey on Tuesday, in an apparent breach of the longstanding Montreux Convention, which prohibits submarines from moving between the Black Sea and the Mediterranean. If the move goes unchecked it could change the balance of power in the region, making Russia more powerful in the Mediterranean.

The submarine was photographed by Yörük Işık, a highly respected ship spotter who lives in Istanbul. There is no mistaking that this is a Kilo Class submarine. Only Russia operates this type of submarine in the Black Sea. Romania also has a sole example on its lists but that hasn’t been active in decades so it cannot be that.

More specifically, the submarine is likely to be the Project 636.3 boat Rostov-on-Don, heading to take up duty in Syria. Russian state media reported on April 27 that the sub would be dispatched on a “deployment in distant waters” to the Mediterranean. Analysis of open-source intelligence suggests that she put to sea briefly after the announcement but then returned to her base on April 29. This was likely to start a pre-deployment COVID-19 isolation. She then participated in the Victory Day parade in Sevastopol, Crimea. She did not actually head south toward the Mediterranean until now.

Without a DNA sequencer, two Los Angeles entomologists relied on two of biology’s oldest tools: microscopes and lots of free time.

Honeywell has been working toward this goal for the past decade when it began developing the technology to produce cryogenics and laser tools. In the past five years, the company assembled a team of more than 100 technologists entirely dedicated to building the machine, and in March, Honeywell announced it would be within three months — a goal it was able to meet even as the Covid-19 turned its workforce upside down and forced some employees to work remotely. “We had to completely redesign how we work in the facilities, had to limit who was coming on the site, and put in place physical barriers,” says Tony Uttley, president of Honeywell Quantum Solutions. “All of that happened at the same time we were planning on being on this race.”

The conglomerate said its machine had reached a Quantum Volume of 64, twice as powerful as IBM’s machine.

One of the world’s greatest anti-aging scientists continues his groundbreaking efforts. In the photo next to Dr David Sinclair, there is a fella who kind of looks like my friend, Dr Yuancheng Ryan Lu. Is that you? (Dr Lu has confirmed that he is indeed the scientist on the right. Dr Sinclair is on the left.)

I can’t wait to see what they develop next!

Harvard scientist David Sinclair is one of Longevity’s big hitters. Just a year after raising $50M in Series B financing, his company Life Biosciences LLC is looking for $100M to progress its anti-aging research [1].

Continue reading “David Sinclair seeks £100m for anti-aging fight” »

With comments from Aubrey de Grey.

Bret Weinstein was interviewed on the Joe Rogan show and Bret claimed that the breeding protocols and telomeres of lab mice are broken. Bret claims that this problem is so severe that it calls into question the safety and correctness of decades of pharmaceutical studies.

Continue reading “Lab Mice Telomeres Do Not Break Them as Disease Models” »

A new experiment suggests DNA and RNA may have formed together before the origin of life.