Lifeboat Foundation

Neurological disorders, such as trauma, stroke, epilepsy, and various neurodegenerative diseases, often lead to the permanent loss of neurons, causing significant impairments in brain function. Current treatment options are limited, primarily due to the challenge of replacing lost neurons.

Direct neuronal reprogramming, a complex procedure that involves changing the function of one type of cell into another, offers a promising strategy.

In cell culture and in living organisms, glial cells—the non-neuronal cells in the central nervous system—have been successfully transformed into functional neurons. However, the processes involved in this reprogramming are complex and require further understanding. This complexity presents a challenge, but also a motivation, for researchers in the field of neuroscience and regenerative medicine.

Arc Institute scientists have discovered the bridge recombinase mechanism, a revolutionary tool that enables fully programmable DNA rearrangements.

Their finding, detailed in a recent Nature publication, is the first DNA recombinase that uses a non-coding RNA for sequence-specific selection of target and donor DNA molecules. This bridge RNA is programmable, allowing the user to specify any desired genomic target sequence and any donor DNA molecule to be inserted.

Continue reading “A ‘Word Processor’ for Genes — Scientists Unveil Fundamentally New Mechanism for Biological Programming” »

The results of this study link volume loss of hippocampal output structures, and in particular the subiculum, to functional cognitive impairment and to amyloid and tau copathologies in Lewy body diseases:

Background and Objectives.

New research identifies some of the genes that could help to explain why lung cancer incidence rises with age but declines after the age of 75.

A new microscopy method has allowed researchers to detect tiny changes in the atomic-level architecture of crystalline materials like advanced steels for ship hulls and custom silicon for electronics. It could advance our ability to understand the fundamental origins of materials properties and behaviour.

In a paper published today in Nature Materials, researchers from the University of Sydney’s School of Aerospace, Mechanical and Mechatronic Engineering introduced a new way to decode the atomic relationships within materials.

The breakthrough could assist in the development of stronger and lighter alloys for the aerospace industry, new generation semiconductors for electronics, and improved magnets for electric motors. It could also enable the creation of sustainable, efficient and cost-effective products.

AcrIF25 inhibits the type I-F CRISPR–Cas system by disassembling its ribonucleoprotein effector complex without an external energy source.

Researchers at Rice University are making strides in understanding how chromosome structures change throughout the cell’s life cycle. Their study on motorized processes that actively influence the organization of chromosomes appears in the Proceedings of the National Academy of Science.

“This research provides a deeper understanding of how motorized processes shape chromosome structures and influence cellular functions,” said Peter Wolynes, study co-author and the D.R. Bullard-Welch Foundation Professor of Science. Wolynes is also a professor of chemistry, biosciences, physics and astronomy and the co-director of the Center for Theoretical Biological Physics (CTBP).

The research introduces two types of motorized chain models: swimming motors and grappling motors. These motors play distinct roles in manipulating chromosome structure.

Understanding how transport networks, such as river systems, form and evolve is crucial to optimizing their stability and resilience. It turns out that networks are not all alike. Tree-like structures are adequate for transport, while networks containing loops are more damage-resistant. What conditions favor the formation of loops?

Researchers from the Faculty of Physics at the University of Warsaw and the University of Arkansas sought to answer this question. The findings, published in Physical Review Letters, show that networks tend to form stable loop structures when flow fluctuations are appropriately tuned. This finding will allow us to understand the structure of dynamic transport networks better.

Transport networks, like blood vessels or river systems, are essential for many natural and human-made systems. Understanding how these networks form and grow is crucial for optimizing their stability and resilience.

New findings reveal that individuals with an average sense of smell may unknowingly be living with natural gas leaks. According to a peer-reviewed study in the scientific journal Environmental Research Letters, minor leaks can deteriorate indoor air quality by emitting various hazardous pollutants, such as benzene—a carcinogen detected in 97% of natural gas samples throughout North America.

“While these smaller leaks are not large enough to cause gas explosions, hard-to-smell leaks are common,” said lead author and PSE Healthy Energy Scientist Sebastian Rowland. “The fact that they are so small makes them hard to identify and fix, which can lead to a persistent indoor source of benzene and methane.”