Lifeboat Foundation

What are epinutrients, you ask? Allow us to explain.

In a 2021 study, naturopathic doctor and functional medicine expert Kara Fitzgerald, N.D., author of Younger You, was able to improve participants’ biological age by three years. Sounds like a tall order, but the intervention was actually pretty simple: With a very doable diet and exercise plan, it only took eight weeks to see these results. “A big reason we actually made a difference in eight weeks’ time is because we very intentionally bathed the body in a high amount of epinutrients,” she says on this episode of the mindbodygreen podcast.

Continue reading “5 Epinutrients To Slow Down Aging, From A Naturopathic Doctor” »

Gene editing approaches promise to treat a range of diseases, but delivering editing agents to cells in animal models and humans safely and efficiently has proven challenging. Now, researchers led by a team at the Broad Institute of MIT and Harvard have developed a way to get gene editing proteins inside cells in animal models with high enough efficiency to show therapeutic benefit.

In new work published in Cell, the team shows how they have engineered virus-like particles to deliver base editors — proteins that make programmable single-letter changes in DNA — and CRISPR-Cas9 nuclease, a protein that cuts DNA at targeted sites in the genome. In collaboration with ​​research teams led by Krzysztof Palczewski at the University of California, Irvine, and Kiran Musunuru at the Perelman School of Medicine at the University of Pennsylvania, the team used their particles, called engineered virus-like particles (eVLPs), to disable a gene in mice that can be associated with high cholesterol levels, and partially restored visual function to mice harboring a mutation that causes genetic blindness.

Researchers have developed virus-like particles that deliver therapeutic levels of protein to animal models of disease.

Continue reading “Engineered particles efficiently deliver gene editing proteins to cells in mice” »

In a new study, researchers at Karolinska Institutet have identified the presence of a specific connection between a protein and an lncRNA molecule in liver cancer. By increasing the presence of the lncRNA molecule, the fat depots of the tumor cell decrease, which causes the division of tumor cells to cease, and they eventually die. The study, published in the journal Gut, contributes to increased knowledge that can add to a better diagnosis and future cancer treatments.

It is 20,000 times smaller than human hair, can communicate using light signals, and could potentially work in any lab in the world.

AI-powered, $13 million drug discovery and development collaboration set to jointly advance multiple targets.

Bioelectricity, the current that flows between our cells, is fundamental to our ability to think and talk and walk.

In addition, there is a growing body of evidence that recording and altering the bioelectric fields of cells and tissue plays a vital role in wound healing and even potentially fighting diseases like cancer and heart disease.

Now, for the first time, researchers at the USC Viterbi School of Engineering have created a molecular device that can do both: Record and manipulate its surrounding bioelectric field.

Cannabis compounds prevented the virus that causes Covid-19 from penetrating healthy human cells, according to a laboratory study published in the Journal of Nature Products.

DeepScribe, an AI-powered medical transcription platform, has raised $30 million in Series A funding led by Nina Achadjian at Index Ventures, with participation from Scale.ai CEO Alex Wang, Figma CEO Dylan Field and existing investors Bee Partners, Stage 2 Capital and 1984 Ventures. The company’s latest round of funding follows its $5.2 million seed round announced in May 2021. DeepScribe was founded in 2017 by Akilesh Bapu, Matthew Ko and Kairui Zeng with the aim of unburdening doctors from tedious data entry and allowing them to focus on their patients.

In 2019, DeepScribe launched its ambient voice AI technology that summarizes natural patient-physician conversations. The idea for DeepScribe was prompted by Bapu and Ko’s own experiences. Bapu’s father was an oncologist and he saw the toll that documentation had on his father’s work/life balance. On the other hand, Ko saw how the burden of clinical documentation was impacting patients’ perception of care when he was the care coordinator for his mother when she was diagnosed with breast cancer.

After being frustrated with the care his mother was receiving, Ko turned to Bapu and his father for help. The pair then began to understand the importance of clinical documentation and realized that recent breakthroughs in artificial intelligence and natural language processing were not being used to remedy the situation. They then decided to create a platform that would address the problem.

A pig’s heart in a human? The bold frontier of xenotransplantation shows just how quickly medical science is evolving.