Lifeboat Foundation

Conventional manufacturing methods such as soft lithography and hot embossing processes can be used to bioengineer microfluidic chips, albeit with limitations, including difficulty in preparing multilayered structures, cost-and labor-consuming fabrication processes as well as low productivity.

Materials scientists have introduced digital light processing as a cost-effective microfabrication approach to 3D print microfluidic chips, although the fabrication resolution of these microchannels are limited to a scale of sub-100 microns.

In a new report published in Microsystems and Nanoengineering, Zhuming Luo and a scientific team in biomedical engineering, and chemical engineering in China developed an innovative digital light processing method.

When you think about it, it seems impossible: a microscope so small and lightweight you can carry it like a keychain. But enter the Make-roscope, an invention of Jeremy De Leon, a 28-year-old Manufacturing Engineering graduate of Mapua University.

Used with a smartphone or tablet—simply place the Make-roscope on top of the gadget’s front camera—the invention can magnify organisms up to 400 times. And because it is made of food-grade silicone and a special type of lens, it is also handy, waterproof, and will be good to use for a very long time. While the principles behind pocket microscopes already exist, Jeremy’s new design innovation provides better ease of use.

Jeremy’s Make-roscope kit, which includes an information card, tweezers, keychain, cleaning cloth, blank glass slides, prepared specimen, pipette, specimen tubes, and cotton swabs, won the biggest prize in the Philippine leg of the James Dyson Award out of 47 entries from 12 universities. Jeremy says he will use the P330,000 prize money to further develop his invention.

The idea that genetic modification can improve humanity isn’t new, but it has taken some interesting turns within the scientific community over the past few years. One of the most notable comes from the mind of He Jiankui, a Chinese scientist whose gene editing of human babies led to infamy and a prison sentence. Now, He, known as JK to friends, thinks that gene-edited humans could be the future of our species.

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“As a child, I wished for a robot that would explain others’ emotions to me” says Sharifa Alghowinem, a research scientist in the Media Lab’s Personal Robots Group (PRG). Growing up in Saudi Arabia, Alghowinem says she dreamed of coming to MIT one day to develop Arabic-based technologies, and of creating a robot that could help herself and others navigate a complex world.

In her early life, Alghowinem faced difficulties with understanding social cues and never scored well on standardized tests, but her dreams carried her through. She earned an undergraduate degree in computing before leaving home to pursue graduate education in Australia. At the Australian National University, she discovered affective computing for the first time and began working to help AI detect human emotions and moods, but it wasn’t until she came to MIT as a postdoc with the Ibn Khaldun Fellowship for Saudi Arabian Women, which is housed in the MIT Department of Mechanical Engineering, that she was finally able to work on a technology with the potential to explain others’ emotions in English and Arabic. Today, she says her work is so fun that she calls the lab “my playground.”

Alghowinem can’t say no to an exciting project. She found one with great potential to make robots more helpful to people by working with Jibo, a friendly robot companion developed by the founder of the Personal Robots Group (PRG) and the social robot startup Jibo Inc., MIT Professor and Dean for Digital Learning Cynthia Breazeal’s research explores the potential for companion robots to go far beyond assistants who obey transactional commands, like requests for the daily weather, adding items to shopping lists, or controlling lighting. At the MIT Media Lab, the PRG team designs Jibo to make him an insightful coach and companion to advance social robotics technologies and research. Visitors to the MIT Museum can experience Jibo’s charming personality.

In the study, published today in Science Translational Medicine, the researchers used engineered CAR T cells to target CD45—a surface marker found on nearly all blood cells, including nearly all blood cancer cells. Because CD45 is found on healthy blood cells too, the research team used CRISPR base-editing to develop a method called “epitope editing” to overcome the challenges of an anti-CD45 strategy, which would otherwise result in low blood counts, with potentially life-threating side effects. The early results represent a proof-of-concept for epitope editing, which involves changing a small piece of the target CD45 molecule just enough so that the CAR T cells don’t recognize it, but it… More.

A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. A new preclinical, proof-of-concept study details the “epitope-editing” approach.

Recent advancements in gene editing technologies may lead to a cure for hemoglobinopathies, including sickle cell disease and β-thalassemia.

A collaborative study between researchers from St Jude Children’s Research Hospital (TN, USA) and the Broad Institute of MIT and Harvard (MA, USA) has shown that adenosine base editing could be more effective than other gene editing approaches such as CRISPR/Cas9 for treating sickle cell disease and β-thalassemia. Comparing five different gene editing strategies utilizing either Cas9 nucleases or adenine base editors in hematopoietic and progenitor stem cells, the team found that base editing yielded more favorable results.

Sickle cell disease and β-thalassemia arise due to mutations in the β-globin subunit of hemoglobin, resulting in defective red blood cells. Previous studies have shown that restoring the function of γ-globin, a hemoglobin submit expressed during fetal development, could hold therapeutic advantages for patients with sickle cell disease and β-thalassemia. During fetal development, γ-globin combines with α-globin to form fetal hemoglobin. Following birth, expression of γ-globin ceases as it is replaced by β-globin to form adult hemoglobin. The researchers sought to see whether fetal hemoglobin expression could be restored in post-natal red blood cells to counter the effects of the disease, offering a potentially universal therapeutic approach for the disease.

The new tool has the capacity to undertake strand-specific gene editing without any cuts.

Chinese researchers claim to have created a new gene-editing technique called CyDENT that is more effective than Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology.

This is according to a report by the South China Morning Post (SCMP) published on Saturday.

Continue reading “Chinese scientists report gene editing tool better than CRISPR” »

The organism fared better at converting organic waste to electricity than even some famous and exotic electricity producing microbes.

Scientists at the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland have successfully engineered E.coli.

Escherichia coli, commonly known as E.coli, is a rod-shaped bacterium commonly found in the lower gut of organisms. However, it has become a favorite of microbial researchers worldwide for the ease with which its genetic structure can be manipulated. It has, therefore, become an indispensable part of research and industrial projects.

For years, researchers have tried various ways to coax quantum bits—or qubits, the basic building blocks of quantum computers—to remain in their quantum state for ever-longer times, a key step in creating devices like quantum sensors, gyroscopes, and memories.

A team of physicists from MIT have taken an important step forward in that quest, and to do it, they borrowed a concept from an unlikely source—noise-cancelling headphones.

Led by Ju Li, the Battelle Energy Alliance Professor in Nuclear Engineering and professor of materials science and engineering, and Paola Cappellaro, the Ford Professor of Engineering in the Department of Nuclear Science and Engineering and Research Laboratory of Electronics, and a professor of physics, the team described a method to achieve a 20-fold increase in the coherence times for nuclear-spin qubits.