A research team from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences has revealed that aging specifically impairs the generation of CD8+ tissue resident memory T cells (TRM) and thus compromises the antitumor defensive activity of aged CD8+ T cells. The study is published in Nature Aging.
With the aging process, the risk of developing cancer significantly increases. In recent years, it has been reported that immune aging has an important impact on tumor development. Immune aging is a degenerative change in the immune system that occurs with aging, leading to a decline in immune response and ultimately triggering diseases including tumors.
Within the immune system, CD8+ T cells are the main defensive adaptive immune cells protecting against tumor cells. However, the mechanism by which aging impairs the antitumor response of CD8+ T cells was not previously understood.
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