Lifeboat Foundation

In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, Ph.D., demonstrates that neural stem cells—the stem cells of the nervous system—age rapidly.

“There is chronological aging, and there is biological aging, and they are not the same thing,” said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. “We’re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer’s disease, epilepsy and brain injury.”

In the study, first author Albina Ibrayeva, a Ph.D. candidate in the Bonaguidi Lab in the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, joined her colleagues in looking at the brains of young, middle-aged and old mice.

The film features Nick Bostrom, author of Superintelligence; Japanese roboticist, Hiroshi Ishiguro; Douglas Rushkoff, author of Team Human; Ben Goertzel, founder of Singularity.net; and Deepak Chopra, who is creating his own A.I. mind twin.

EXCLUSIVE: Here’s the first trailer for Hot Docs opener Artificial Immortality by filmmaker Ann Shin.

The documentary explores the latest advancements in AI, robotics and biotech with visionaries who argue for a new age of post-biological life. It poses the questions: if you were able to create an immortal version of yourself, would you?; and will AI be the best, or the last thing we ever do as a species?

Continue reading “‘Artificial Immortality’: Watch The First Trailer For Hot Docs Opener About AI & Biotech” »

Aging is maleable and can be intervened to slow down and even reverse it.
Several experiments in animal models have shown that certain gene therapies as well as interventions via partial cellular reprograming can significantly extend healthspan and lifespan in mice and other model organisms.

An article published on December 30, 2020 in Fortune magazine, reaches the following conclusions:
* Without treatments to slow or reverse aspects of biological aging, an aging population means we are in for a health care cost tsunami.
* The most exciting opportunity for such an improvement in health productivity is to understand and address the biology of aging.
* There is promising scientific research on reversing aspects of aging, some of which is not far from clinical application.
* While all this research represents thrilling progress, we invest far too little in research that could help us go further in understanding and treating aging.

Continue reading “Aging isn’t nice — Let’s bring world leaders to the quest of solving it” »

Papers referenced int the video:

Deficient synthesis of glutathione underlies oxidative stress in aging and.
can be corrected by dietary cysteine and glycine supplementation:
https://pubmed.ncbi.nlm.nih.gov/21795440/

Continue reading “Glutathione Restoration Improves Hallmarks Of Aging in Older Adults” »

The question cryogenics raises is, can we freeze and then recover consciousness itself as opposed to simply saving imprints of a person’s memories as an AI?

Long article, good history, and a warning.

Biotech startups are trying to hack the process of aging and, in the process, stave off the most devastating diseases.

Delaying, Detecting, Preventing and Treating Aging And Associated Diseases — Dr. Brian Kennedy, Ph.D., National University of Singapore.

Dr. Brian Kennedy is Distinguished Professor, Department of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Director of National University Health System (NUHS) Centre for Healthy Ageing, Singapore, Professor, Buck Institute for Research on Ageing, Adjunct Professor, Leonard Davis School of Gerontology, USC, and Affiliate Faculty, Department of Biochemistry, University of Washington.

Continue reading “Dr. Brian Kennedy Ph.D. — Delaying, Detecting, Preventing and Treating Aging And Associated Diseases” »

You hear so much about the wonders of coffee, that I decided it was time to even the score.

Tea Is Fantastic.

Continue reading “Tea Is Fantastic — Let’s Hear It For The Humble Cuppa” »

If we look at the mortality tables, it can explain why reversing aging damage reversal has to work very well for people to live very long lives.

Let us imagine that we are able to reverse aging damage so that someone is 65 or older has the same amount of aging as someone who is 65. This means for an average American man, then half of those people will still be dead by the time they have reached 95 years of age. This is because 1.6% of them are dying every year in the 65-year-old condition. Also, only 80% of them have survived from birth to the age of 65.

Asian American women in New Jersey live to a life expectancy of 93. Half of them reach the age of 93. Antiaging that reverses the aging damage every year for men so that they never get worse physically than when they are 65, get them to a life expectancy that is just beyond what Asian American women in New Jersey already achieve.