Lifeboat Foundation

When cities transform into a colorful world of lights as darkness falls, it’s often only possible to estimate their contours, which depending on the perspective can draw the attention to key details or trivia. In fluorescence microscopy, biological cells are marked with fluorescent dyes and excited to luminesce in specific areas by optical switches– like a city at night. However, this light is usually too faint for small, rapid objects, or even goes out after a while. This is known as fluorescence bleaching.

Now, a new approach developed by Prof. Dr. Alexander Rohrbach and his team in the Laboratory for Bio-and Nano-Photonics at the University of Freiburg has found a way to make the smallest objects clearly visible without fluorescence. In this way, cellular structures or virus-sized particles can be observed 100 to 1,000 times longer, ten to 100-times faster and with almost doubled resolution than with fluorescence microscopy. While fluorescence microscopy records what you might call “night-time images” of structures, ROCS microscopy takes “day-time images”—opposites that can complement each other excellently. Rohrbach and his colleagues describe various applications of the technology in the latest issue of Nature Communications.

Very good news, if unsurprising.

We already have multiple viable avenues of reducing — or eliminating altogether — this particularly pernicious form of remorseless biological entropy.

So good news… UNLESS you’re one of those people who think death is what MAKES life somehow MEANINGFUL, or that living for thousands of years or more would be BORING.

Continue reading “Mystery of why humans die around 80 may finally be solved” »

Circa 2015

Engineers from the University of California, San Diego have developed an ultra-thin temporary tattoo that can painlessly and accurately monitor the glucose levels of diabetics.

The flexible device costs just a few cents and lasts for a day at a time, and early tests have shown that it’s just as sensitive as a finger-prick test.

Continue reading “This Temporary Tattoo Can Monitor Diabetics’ Glucose Levels as Accurately as a Finger Prick” »

The Interventions Testing Program is the gold standard for testing longevity drugs. What do the results say about which ones extend lifespan in mice? Rapamycin is a big winner!

New podcast w/ Richard Miller on the data on several longevity supplements including Acarbose, NR, Resveratrol, Fisetin, MCT Oil, Curcumin, Fish Oil + more!

Continue reading “Longevity Supplements — What Works & What Doesn’t?” »

Sending miniature robots deep inside the human skull to treat brain disorders has long been the stuff of science fiction—but it could soon become reality, according to a California start-up.

Bionaut Labs plans its first clinical trials on humans in just two years for its tiny injectable robots, which can be carefully guided through the brain using magnets.

“The idea of the micro robot came about way before I was born,” said co-founder and CEO Michael Shpigelmacher.

In a small trial, immune cells that fight the Epstein-Barr virus have stopped the progression of multiple sclerosis, an autoimmune condition that can lead to symptoms, such as difficulty walking, that worsen over time.

Summary: Researchers identified a genetic correlation between blood biomarkers and a range of mental health disorders. The study provides evidence some substance measures within the blood may be involved in the cause of mental illnesses. For example, immune system proteins may be involved in the development of depression, schizophrenia, and anorexia.

Source: The Conversation.

Mental health disorders including depression, schizophrenia, and anorexia show links to biological markers detected in routine blood tests, according to our new study of genetic, biochemical and psychiatric data from almost a million people.

Supercomputers are extremely fast, but also use a lot of power. Neuromorphic computing, which takes our brain as a model to build fast and energy-efficient computers, can offer a viable and much-needed alternative. The technology has a wealth of opportunities, for example in autonomous driving, interpreting medical images, edge AI or long-haul optical communications. Electrical engineer Patty Stabile is a pioneer when it comes to exploring new brain-and biology-inspired computing paradigms. “TU/e combines all it takes to demonstrate the possibilities of photon-based neuromorphic computing for AI applications.”

Patty Stabile, an associate professor in the department of Electrical Engineering, was among the first to enter the emerging field of photonic neuromorphic computing.

“I had been working on a proposal to build photonic digital artificial neurons when in 2017 researchers from MIT published an article describing how they developed a small chip for carrying out the same algebraic operations, but in an analog way. That is when I realized that synapses based on analog technology were the way to go for running artificial intelligence, and I have been hooked on the subject ever since.”

Collective dynamics are ubiquitous in the natural world. From neural circuits to animal groups, there are countless instances in which the interactions among large numbers of elementary units bestow surprisingly complex patterns of tantalizing beauty on the collective. One of the longstanding goals of researchers in many fields is to understand behaviors of a large group of individual units by monitoring the actions of a single unit. For example, an ornithologist can learn many things about the behaviors of a flock by monitoring only a single bird.

Of greater difficulty is understanding the size of a collection of units by observing a single unit. No matter how many birds one tags with monitoring equipment, one can never be assured of having tagged the entire flock. Yet, while the ability to calculate the size of a collective from individual behaviors would be a key tool for any field, there are only a handful of recent papers trying to tackle the seemingly unsolvable problem.

In a newly published study appearing in Communications Physics, investigators led by Maurizio Porfiri, Institute Professor of Mechanical and Aerospace Engineering and Biomedical Engineering, and a member of the Center for Urban Science and Progress (CUSP) at the NYU Tandon School of Engineering; and Pietro De Lellis of the University of Naples, Italy, offer a paradigm to solve this problem, one that builds upon precepts that can be traced back to the work of Einstein.