Lifeboat Foundation

Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade.

WASHINGTON (AP) — Drugmaker Moderna asked the Food and Drug Administration on Thursday to authorize a fourth shot of its COVID-19 vaccine as a booster dose for all adults.

The request is broader than rival pharmaceutical company Pfizer’s request earlier this week for the regulator to approve a booster shot for all seniors.

In a press release, the company said its request for approval for all adults was made “to provide flexibility” to the Centers for Disease Control and Prevention and medical providers to determine the “appropriate use” of a second booster dose of the mRNA vaccine, “including for those at higher risk of COVID-19 due to age or comorbidities.”

A research team from KTH Royal Institute of Technology and Max Planck Institute of Colloids and Interfaces reports to have found the key to controlled fabrication of cerium oxide mesocrystals. The research is a step forward in tuning nanomaterials that can serve a wide range of uses—including solar cells, fuel catalysts and even medicine.

Mesocrystals are nanoparticles with identical size, shape and crystallographic orientation, and they can be used as building blocks to create artificial nanostructures with customized optical, magnetic or electronic properties. In nature, these three-dimensional structures are found in coral, sea urchins and calcite desert rose, for example. Artificially-produced cerium oxide (CeO₂) mesocrystals—or nanoceria—are well-known as catalysts, with antioxidant properties that could be useful in pharmaceutical development.

“To be able to fabricate CeO₂ mesocrystals in a controlled way, one needs to understand the formation mechanism of these materials,” says Inna Soroka, a researcher in applied physical chemistry at KTH. She says the team used radiation chemistry to reveal for the first time the ceria mesocrystal formation mechanism.

Re-engineering clinical trials around participants — katie baca-motes, co-founder, scripps research digital trials center, scripps research.

Katie Baca-Motes, MBA, (https://www.scripps.edu/science-and-medicine/translational-i…aca-motes/) is Senior Director, Strategic Initiatives at the Scripps Research Translational Institute, and Co-Founder of the Scripps Research Digital Trials Center (https://digitaltrials.scripps.edu/).

Continue reading “Katie Baca-Motes — Co-Founder, Scripps Research Digital Trials Ctr — Re-Engineering Clinical Trials” »

Could Aliens Get Cancer? What is it´s root cause and would cancer evolve in an Alien Biosphere?

Would you share your data for the common good? Biomechanist Jacqueline Alderson shows how sophisticated simulations based on real data can help prevent disease, illness and injury. Jacqueline Alderson is an Associate Professor of Biomechanics at the University of Western Australia and Adjunct Professor of Human Performance, Innovation and Technology at the Auckland University of Technology. She has always been curious about movement — whether it’s helping surgeons make best practice decisions or helping AFL players avoid knee injuries. She now travels the world to share her knowledge in human movement, wearable tech and artificial intelligence and its role in tracking, analysing and intervening in the human condition. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

While many people in wealthier countries have been vaccinated against COVID-19, there is still a need for vaccination in much of the world. A new vaccine developed at MIT and Beth Israel Deaconess Medical Center may aid in those efforts, offering an inexpensive, easy-to-store, and effective alternative to RNA vaccines.

In a new paper, the researchers report that the vaccine, which comprises fragments of the SARS-CoV-2 spike protein arrayed on a virus-like particle, elicited a strong immune response and protected animals against viral challenge.

The vaccine was designed so that it can be produced by yeast, using fermentation facilities that already exist around the world. The Serum Institute of India, the world’s largest manufacturer of vaccines, is now producing large quantities of the vaccine and is running a clinical trial in Africa.

Dry, hot regions are difficult places to grow plants because the soil dries out quickly. As a result, farmers in arid and semi-arid regions irrigate their fields with buried networks of irrigation tubing and cover the ground with plastic sheets. But plastic sheets are expensive and create waste. Now, researchers reporting in ACS Agricultural Science & Technology have developed a simple, biodegradable ground cover—wax-coated sand—which keeps soil wet and increases crop yields.

To irrigate crops, farmers usually get water from nearby waterways or underground aquifers. These supplies can be rapidly depleted when growing plants in arid regions, where the soil is comprised mostly of sand and can’t hold onto water well. One way to improve irrigated water’s efficiency is to make sure it stays in the soil long enough so that plants’ roots can take it up. Previous studies have shown that ground cover barriers, such as plastic sheets and engineered nanomaterials, can slow evaporation and enhance plant growth and crop yields. However, both could leach unwanted compounds into the soil with unknown long-term impacts. Some plants and animals naturally produce waxy substances that trap and pool water from fog or condensation so that they can access these moisture sources. Taking inspiration from nature, Himanshu Mishra and colleagues wanted to see if they could coat sand with wax, creating an environmentally benign ground cover to control soil evaporation.

The researchers chose purified paraffin wax, a biodegradable substance available in large quantities, for their experiments. They dissolved the wax in hexane and poured silica sand into the mixture. As the solvent evaporated, a 20-nm-thick coating of wax was left behind on the grains. When the team applied the wax-coated sand in a thin layer on an open field in Saudi Arabia, it decreased the loss of soil moisture up to 50–80%. Field trials revealed that tomato, barley and wheat plants mulched with the new material produced substantially more fruit and grain than those grown in uncovered soil. In addition, the microbial community around the plants’ roots and in the soil wasn’t negatively impacted by the waxy mulch, which could have acted as a food source for some of the microbes. This simple nature-inspired technology could make water use more efficient in arid regions, the researchers say.